2024
Contemporary management of aneurysmal subarachnoid haemorrhage. An update for the intensivist
Robba C, Busl K, Claassen J, Diringer M, Helbok R, Park S, Rabinstein A, Treggiari M, Vergouwen M, Citerio G. Contemporary management of aneurysmal subarachnoid haemorrhage. An update for the intensivist. Intensive Care Medicine 2024, 50: 646-664. PMID: 38598130, PMCID: PMC11078858, DOI: 10.1007/s00134-024-07387-7.Peer-Reviewed Original ResearchMeSH KeywordsAneurysm, RupturedCritical CareHumansIntensive Care UnitsPrognosisSubarachnoid HemorrhageConceptsIntensive care unitAneurysmal subarachnoid haemorrhageRuptured aneurysmsLong-term prognostic factorsRisk of rebleedingIntensive care unit managementRobust clinical evidenceDelayed cerebral ischaemiaExpert clinical experienceSecondary brain damageDeterminants of functional outcomePrognostic factorsASAH patientsPrompt diagnosisHaemodynamic monitoringClinical evidenceMorbidity rateSpecialized centersTreatment strategiesClinical trialsContemporary guidelinesPatient populationFunctional outcomesCare unitCerebral ischaemia
2013
Predictors of Reintubation in Critically Ill Patients
Miu T, Joffe AM, Yanez ND, Khandelwal N, Dagal AH, Deem S, Treggiari MM. Predictors of Reintubation in Critically Ill Patients. Respiratory Care 2013, 59: 178-185. PMID: 23882103, DOI: 10.4187/respcare.02527.Peer-Reviewed Original ResearchConceptsAcute Physiology Score IIDiastolic blood pressureExtubation failureScore IIBlood pressureMinute ventilationAdmission Simplified Acute Physiology Score IISimplified Acute Physiology Score IIRapid shallow breathing indexMultivariable logistic regression analysisPredictors of reintubationTertiary care centerShallow breathing indexAdditional independent predictorsBivariate logistic regression modelLogistic regression analysisLogistic regression modelsICU extubationExtubation successICU admissionBaseline characteristicsCohort studyIll patientsIndependent predictorsBreathing index
2012
Pseudomonas aeruginosa serology and risk for re-isolation in the EPIC trial
Anstead M, Heltshe SL, Khan U, Barbieri JT, Langkamp M, Döring G, Dharia S, Gibson RL, Treggiari MM, Lymp J, Rosenfeld M, Ramsey B. Pseudomonas aeruginosa serology and risk for re-isolation in the EPIC trial. Journal Of Cystic Fibrosis 2012, 12: 147-153. PMID: 22944725, PMCID: PMC3696392, DOI: 10.1016/j.jcf.2012.08.001.Peer-Reviewed Original ResearchConceptsPulmonary exacerbationsCF patientsP. aeruginosa eradicationP. aeruginosa isolationCystic fibrosis patientsEarly P. aeruginosaBaseline seropositivityEPIC trialPositive serologyAntibiotic therapyChild TrialTreatment failurePrognostic valuePseudomonas infectionWeek 10Fibrosis patientsSerologyCulture resultsPatientsClinicians' effortsExacerbationSeropositivityP. aeruginosaRiskTrialsMortality and long-term functional outcome associated with intracranial pressure after traumatic brain injury
Badri S, Chen J, Barber J, Temkin NR, Dikmen SS, Chesnut RM, Deem S, Yanez ND, Treggiari MM. Mortality and long-term functional outcome associated with intracranial pressure after traumatic brain injury. Intensive Care Medicine 2012, 38: 1800-1809. PMID: 23011528, DOI: 10.1007/s00134-012-2655-4.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryAverage intracranial pressureIntracranial pressureFunctional statusTBI patientsBrain injuryNeuropsychological functioningAbbreviated Injury Scale headLong-term functional outcomeSevere traumatic brain injuryAdult TBI patientsInjury scale headGlasgow Coma ScoreSevere TBI patientsPrimary endpointComa ScoreComposite endpointIndependent predictorsFunctional outcomeOdds ratioMultivariable regressionNeuropsychological outcomesNeuropsychological testingPatientsNeuropsychological function
2011
The association between fluid balance and outcomes after subarachnoid hemorrhage
Martini RP, Deem S, Brown M, Souter MJ, Yanez ND, Daniel S, Treggiari MM. The association between fluid balance and outcomes after subarachnoid hemorrhage. Neurocritical Care 2011, 17: 191-198. PMID: 21688008, DOI: 10.1007/s12028-011-9573-0.Peer-Reviewed Original ResearchConceptsPositive fluid balanceICU day 3Negative fluid balanceFluid balanceNew strokeSubarachnoid hemorrhageDay 3Early fluid balanceLevel 1 traumaCumulative fluid balanceWorse clinical presentationMultivariable logistic regressionLess urine outputHunt-Hess scoreGreater resource useTCD vasospasmHospital deathHospital mortalityICU admissionTroponin elevationAdmission GCSHospital courseHospital lengthAdult patientsPrimary outcome
2009
Management guided by brain tissue oxygen monitoring and outcome following severe traumatic brain injury.
Martini RP, Deem S, Yanez ND, Chesnut RM, Weiss NS, Daniel S, Souter M, Treggiari MM. Management guided by brain tissue oxygen monitoring and outcome following severe traumatic brain injury. Journal Of Neurosurgery 2009, 111: 644-9. PMID: 19392603, DOI: 10.3171/2009.2.jns08998.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain InjuriesCohort StudiesFemaleHealth ResourcesHospital CostsHospital MortalityHumansIntracranial PressureLength of StayMaleMiddle AgedMonitoring, PhysiologicOxygenPrognosisRegression AnalysisRespiration, ArtificialRetrospective StudiesTrauma Severity IndicesTreatment OutcomeConceptsBrain tissue oxygen monitoringHospital mortality rateTissue oxygen monitoringTraumatic brain injurySevere traumatic brain injuryMortality rateBrain injuryHospital lengthNeurological outcomeHospital dischargeClinical managementICP monitoringMedian hospital lengthWorse neurological outcomeHospital resource utilizationOxygen monitoringMain outcome measuresFunctional Independence ScoreIntracranial pressure monitoringSeverity of injuryBaseline characteristicsCohort studyPatient ageMore patientsOsmotic therapy
2004
Effect of acute lung injury and acute respiratory distress syndrome on outcome in critically ill trauma patients*
Treggiari MM, Hudson LD, Martin DP, Weiss NS, Caldwell E, Rubenfeld G. Effect of acute lung injury and acute respiratory distress syndrome on outcome in critically ill trauma patients*. Critical Care Medicine 2004, 32: 327-331. PMID: 14758144, DOI: 10.1097/01.ccm.0000108870.09693.42.Peer-Reviewed Original ResearchConceptsALI/acute respiratory distress syndromeAcute respiratory distress syndromeAcute lung injuryAcute Physiology ScoreRespiratory distress syndromeTrauma patientsHospital mortalityPhysiology ScoreLung injuryDistress syndromeSeverity scoreHospital costsTrauma severityAmerican-European Consensus Conference definitionPresence of ALIIntensive care unit admissionIntensive care unit stayIll trauma patientsCare unit admissionInjury Severity ScoreConsensus Conference definitionLevel I centersCrude relative riskIntensive care unitLength of stay
2002
Postmenopausal hormone use and skeletal fracture: does the size of the benefit decrease with increasing age?
Weiss NS, Treggiari MM. Postmenopausal hormone use and skeletal fracture: does the size of the benefit decrease with increasing age? Obstetrics And Gynecology 2002, 100: 364-8. PMID: 12151165, DOI: 10.1016/s0029-7844(02)02046-x.Peer-Reviewed Original ResearchConceptsLong-term hormone useOlder postmenopausal womenPostmenopausal womenHormone useFracture riskYounger postmenopausal womenPostmenopausal hormone useSurrogate end pointsBone mineral densityUse of hormonesHormone therapySkeletal benefitsRandomized trialsSuch therapyMineral densitySkeletal fracturesAbsolute reductionEnd pointStudy of hormonesWomenHealth careTrialsAgeTrue declineRisk