2011
Open-Label Randomized Trial of the Safety and Efficacy of a Single Dose Conivaptan to Raise Serum Sodium in Patients with Traumatic Brain Injury
Galton C, Deem S, Yanez ND, Souter M, Chesnut R, Dagal A, Treggiari M. Open-Label Randomized Trial of the Safety and Efficacy of a Single Dose Conivaptan to Raise Serum Sodium in Patients with Traumatic Brain Injury. Neurocritical Care 2011, 14: 354-360. PMID: 21409494, DOI: 10.1007/s12028-011-9525-8.Peer-Reviewed Original ResearchConceptsTraumatic brain injurySevere traumatic brain injuryUsual care groupIntracranial pressureSerum sodiumAdverse eventsUrine outputCare groupSodium loadBrain injuryDrug-related serious adverse eventsEffects of conivaptanLabel Randomized TrialNon-hyponatremic patientsSerum sodium increaseSerious adverse eventsTreatment of hyponatremiaSodium increasesMethodsOpen-labelNormonatremic patientsPrimary endpointResultsTen patientsSecondary endpointsUsual careMean sodium
2004
Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response
Gozzoli V, Treggiari MM, Kleger GR, Roux-Lombard P, Fathi M, Pichard C, Romand JA. Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response. Intensive Care Medicine 2004, 30: 401-407. PMID: 14722642, DOI: 10.1007/s00134-003-2087-2.Peer-Reviewed Original ResearchConceptsCytokine concentrationsInflammatory responseEffects of antipyresisMean arterial pressureTertiary university hospitalC-reactive proteinEnergy expenditure indexUndesirable hemodynamic effectsBody temperatureIntravenous propacetamolMetamizol groupPropacetamol groupHemodynamic effectsSurgical ICUArterial pressureIll patientsUrine outputUnstable patientsHemodynamic variablesUniversity HospitalInterleukin-6Physical therapyTreatment groupsPropacetamolMetamizol