2016
Characteristics of Sepsis-Induced Cardiac Dysfunction using Speckle-Tracking Echocardiography: A Feasibility Study
Zaky A, Gill EA, Lin CP, Paul CP, Bendjelid K, Treggiari MM. Characteristics of Sepsis-Induced Cardiac Dysfunction using Speckle-Tracking Echocardiography: A Feasibility Study. Anaesthesia And Intensive Care 2016, 44: 65-76. PMID: 26673591, PMCID: PMC5050013, DOI: 10.1177/0310057x1604400111.Peer-Reviewed Original ResearchConceptsLeft ventricular longitudinal strainGlobal left ventricular longitudinal strainEjection fractionSepsis outcomeSepsis-Induced Cardiac DysfunctionLeft ventricular ejection fractionTwo-dimensional speckle trackingBasal anterior segmentLow ejection fractionPrimary study endpointTertiary care centerObservational feasibility studyVentricular ejection fractionDiagnosis of sepsisVentricular longitudinal strainSpeckle-tracking echocardiographyRisk of mortalitySpeckle tracking echocardiographyEnd-diastolic volumeMitral annular displacementLeft ventricular segmentsHospital mortalityHospital lengthHospital staySevere sepsis
2014
Characterization of Cardiac Dysfunction in Sepsis
Zaky A, Deem S, Bendjelid K, Treggiari MM. Characterization of Cardiac Dysfunction in Sepsis. Shock 2014, 41: 12-24. PMID: 24351526, DOI: 10.1097/shk.0000000000000065.Peer-Reviewed Original ResearchConceptsSepsis-induced cardiomyopathyIntrinsic contractile functionContractile functionIntrinsic myocardial dysfunctionIntrinsic myocardial functionGlobal ventricular performanceCommon morbid conditionSevere sepsisSeptic shockCardiac dysfunctionHemodynamic assessmentMyocardial dysfunctionCardiac outputPeripheral circulationVentricular performanceAdditional potential mechanismMyocardial functionMorbid conditionsClinical characterizationCurrent evidenceHeart functionPhysiologic mechanismsPhysiopathological pathwaysAnimal modelsCellular signaling mechanisms