2016
Randomized Pilot Trial of Two Modified Endotracheal Tubes To Prevent Ventilator-associated Pneumonia
Deem S, Yanez D, Sissons-Ross L, Broeckel JA, Daniel S, Treggiari M. Randomized Pilot Trial of Two Modified Endotracheal Tubes To Prevent Ventilator-associated Pneumonia. Annals Of The American Thoracic Society 2016, 13: 72-80. PMID: 26523433, PMCID: PMC4722846, DOI: 10.1513/annalsats.201506-346oc.Peer-Reviewed Original ResearchConceptsEndotracheal tubeTracheal colonizationChest radiograph criteriaOccurrence of VAPPrevention of VAPCoprimary end pointsSerious adverse eventsInstitutional review board approvalEmergency endotracheal intubationStandard endotracheal tubeMajority of intubationsReview board approvalModified Endotracheal TubeSafety concernsAdverse eventsVAP preventionEndotracheal intubationSubglottic secretionsEmergency intubationClinical trialsClinical signsNosocomial infectionsPilot trialStudy groupHospital setting
2011
Open-Label Randomized Trial of the Safety and Efficacy of a Single Dose Conivaptan to Raise Serum Sodium in Patients with Traumatic Brain Injury
Galton C, Deem S, Yanez ND, Souter M, Chesnut R, Dagal A, Treggiari M. Open-Label Randomized Trial of the Safety and Efficacy of a Single Dose Conivaptan to Raise Serum Sodium in Patients with Traumatic Brain Injury. Neurocritical Care 2011, 14: 354-360. PMID: 21409494, DOI: 10.1007/s12028-011-9525-8.Peer-Reviewed Original ResearchConceptsTraumatic brain injurySevere traumatic brain injuryUsual care groupIntracranial pressureSerum sodiumAdverse eventsUrine outputCare groupSodium loadBrain injuryDrug-related serious adverse eventsEffects of conivaptanLabel Randomized TrialNon-hyponatremic patientsSerum sodium increaseSerious adverse eventsTreatment of hyponatremiaSodium increasesMethodsOpen-labelNormonatremic patientsPrimary endpointResultsTen patientsSecondary endpointsUsual careMean sodium