2021
Adherence to Guidelines for the Administration of Intraoperative Antibiotics in a Nationwide US Sample
Bardia A, Treggiari MM, Michel G, Dai F, Tickoo M, Wai M, Schuster K, Mathis M, Shah N, Kheterpal S, Schonberger RB. Adherence to Guidelines for the Administration of Intraoperative Antibiotics in a Nationwide US Sample. JAMA Network Open 2021, 4: e2137296. PMID: 34905007, PMCID: PMC8672234, DOI: 10.1001/jamanetworkopen.2021.37296.Peer-Reviewed Original ResearchConceptsSurgical site infectionAntibiotic prophylaxis guidelinesWeight-adjusted dosingInfectious Diseases SocietyAntibiotic choiceProphylaxis guidelinesCohort studyDiseases SocietyOverall adherenceFuture quality improvement effortsStudy periodAntibiotic administration guidelinesPrimary end pointTiming of administrationGynecological surgical proceduresQuality improvement effortsIntraoperative antibioticsOverall nonadherenceNoncardiac surgeryAdult patientsEmergency surgeryFirst doseGuideline adherenceSurgical encountersAmerica guidelines
2020
Randomized Pilot Trial of Acute Normovolemic Hemodilution in Pediatric Cardiac Surgery Patients
Harris WM, Treggiari MM, LeBlanc A, Giacomuzzi C, You JJ, Muralidaran A, Shen I. Randomized Pilot Trial of Acute Normovolemic Hemodilution in Pediatric Cardiac Surgery Patients. World Journal For Pediatric And Congenital Heart Surgery 2020, 11: 452-458. PMID: 32645767, DOI: 10.1177/2150135120923627.Peer-Reviewed Original ResearchConceptsPediatric cardiac surgery patientsAcute normovolemic hemodilutionCardiac surgery patientsSecondary end pointsSurgery patientsEnd pointPostoperative outcomesUsual careBlood transfusionCardiac surgeryNormovolemic hemodilutionHeart surgeryBlood productsPilot trialPediatric heart surgery patientsMarkers of morbidityAllogenic blood transfusionPrimary end pointHeart surgery patientsLong-term morbidityBlood conservation strategiesWorse postoperative outcomesPediatric heart surgeryIntensive care unitBlood component therapy
2019
Inhaled Iloprost Versus Epoprostenol in Heart Transplant Recipients
Enomoto TM, Treggiari MM, Yanez ND, Merkel MJ. Inhaled Iloprost Versus Epoprostenol in Heart Transplant Recipients. Respiratory Care 2019, 64: 743-751. PMID: 30967439, DOI: 10.4187/respcare.06426.Peer-Reviewed Original ResearchConceptsAcute right ventricular dysfunctionHeart transplant recipientsRight ventricular dysfunctionMechanical ventilationEnd pointHeart transplantationHospital stayTransplant recipientsVentricular dysfunctionHemodynamic valuesMedian numberAcute pulmonary hypertensionLength of ICUOrthotopic heart transplantationPrimary end pointSafety end pointSecondary end pointsImmediate postoperative periodPrimary vasodilatorVasoactive medicationsVasodilatory therapyPostoperative bleedingPulmonary hypertensionPostoperative periodConsecutive patients
2017
Process Improvement Initiative for the Perioperative Management of Patients With a Cardiovascular Implantable Electronic Device
Ellis MKM, Treggiari MM, Robertson JM, Rozner MA, Graven PF, Aziz MF, Merkel MJ, Kahl EA, Cohen NA, Stecker EC, Schulman PM. Process Improvement Initiative for the Perioperative Management of Patients With a Cardiovascular Implantable Electronic Device. Anesthesia & Analgesia 2017, 125: 58-65. PMID: 28319519, DOI: 10.1213/ane.0000000000001953.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAgedAged, 80 and overCardiac Surgical ProceduresCardiovascular SystemCohort StudiesDefibrillators, ImplantableFemaleHealth Care CostsHumansMaleMiddle AgedOperating RoomsOutcome and Process Assessment, Health CarePacemaker, ArtificialPatient SafetyPerioperative CarePerioperative PeriodRisk AssessmentTime FactorsConceptsCardiovascular implantable electronic devicesSafe perioperative carePreintervention periodPostintervention periodImplantable electronic devicesPerioperative carePerioperative surgical home modelPrimary end pointCohort of patientsSame eligibility criteriaLarge academic medical centerPatient Safety DatabaseImprovement initiativesAcademic medical centerAdequate patient safetyNew care modelsImproved operating room efficiencyBaseline characteristicsAdverse eventsPerioperative managementPotential confoundersConcurrent cohortDay surgerySurgical proceduresCare model
2015
Dexmedetomidine Does Not Affect Evoked Potentials During Spine Surgery
Rozet I, Metzner J, Brown M, Treggiari MM, Slimp JC, Kinney G, Sharma D, Lee LA, Vavilala MS. Dexmedetomidine Does Not Affect Evoked Potentials During Spine Surgery. Anesthesia & Analgesia 2015, 121: 492-501. PMID: 26097987, DOI: 10.1213/ane.0000000000000840.Peer-Reviewed Original ResearchMeSH KeywordsAnesthesia, IntravenousAnesthetics, IntravenousDexmedetomidineDouble-Blind MethodEvoked PotentialsEvoked Potentials, MotorEvoked Potentials, SomatosensoryEvoked Potentials, VisualFemaleHumansHypnotics and SedativesIntraoperative Neurophysiological MonitoringMaleMiddle AgedOrthopedic ProceduresPiperidinesPropofolReaction TimeRemifentanilSpineTime FactorsConceptsEffect of dexmedetomidineVisual EPsSpine surgeryEnd pointElective spine surgeryPlacebo-controlled trialPrimary end pointSecondary end pointsLatency N1Motor EPsPlacebo groupStudy drugAdult patientsNormal salineLatency P1DexmedetomidineSomatosensory EPsIRB approvalRelevant dosesEP recordingInformed consentPatientsSurgeryEvoked PotentialsAnesthesia
2011
Comparative Efficacy and Safety of 4 Randomized Regimens to Treat Early Pseudomonas aeruginosa Infection in Children With Cystic Fibrosis
Treggiari MM, Retsch-Bogart G, Mayer-Hamblett N, Khan U, Kulich M, Kronmal R, Williams J, Hiatt P, Gibson RL, Spencer T, Orenstein D, Chatfield BA, Froh DK, Burns JL, Rosenfeld M, Ramsey BW, Investigators F. Comparative Efficacy and Safety of 4 Randomized Regimens to Treat Early Pseudomonas aeruginosa Infection in Children With Cystic Fibrosis. JAMA Pediatrics 2011, 165: 847-856. PMID: 21893650, PMCID: PMC3991697, DOI: 10.1001/archpediatrics.2011.136.Peer-Reviewed Original ResearchConceptsPseudomonas aeruginosa infectionCulture-based therapyCulture-based groupsCystic fibrosisAeruginosa infectionEarly Pseudomonas aeruginosa infectionTobramycin inhalation solutionPrimary end pointRate of exacerbationsExacerbation rateIntravenous antibioticsOral ciprofloxacinOral placeboAntibiotic regimensPulmonary exacerbationsAdverse eventsTreat analysisMulticenter trialAntipseudomonal treatmentInhalation solutionOdds ratioComparative efficacyPlaceboEnd pointFibrosis