2009
Early anti-pseudomonal acquisition in young patients with cystic fibrosis: Rationale and design of the EPIC clinical trial and observational study,
Treggiari MM, Rosenfeld M, Mayer-Hamblett N, Retsch-Bogart G, Gibson RL, Williams J, Emerson J, Kronmal RA, Ramsey BW, Group E. Early anti-pseudomonal acquisition in young patients with cystic fibrosis: Rationale and design of the EPIC clinical trial and observational study,. Contemporary Clinical Trials 2009, 30: 256-268. PMID: 19470318, PMCID: PMC2783320, DOI: 10.1016/j.cct.2009.01.003.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnti-Bacterial AgentsChildChild, PreschoolCiprofloxacinCohort StudiesCystic FibrosisDouble-Blind MethodDrug Administration ScheduleDrug Therapy, CombinationFemaleHumansInfantLongitudinal StudiesMalePseudomonas aeruginosaPseudomonas InfectionsRisk FactorsTobramycinTreatment OutcomeConceptsEarly Pa infectionYoung CF patientsRespiratory culturesRisk factorsCystic fibrosisCohort studyPA infectionClinical trialsObservational studyCF patientsEarly CF lung diseaseProgressive obstructive pulmonary diseaseProportion of patientsClinical efficacy dataObstructive pulmonary diseasePositive respiratory culturesPatients ages 1Longitudinal cohort studyCF lung diseaseChronic endobronchial infectionInfection control programPa acquisitionPA-negative patientsOral ciprofloxacinOral placebo
2002
Air cysts and bronchiectasis prevail in nondependent areas in severe acute respiratory distress syndrome: A computed tomographic study of ventilator-associated changes
Treggiari MM, Romand JA, Martin JB, Suter PM. Air cysts and bronchiectasis prevail in nondependent areas in severe acute respiratory distress syndrome: A computed tomographic study of ventilator-associated changes. Critical Care Medicine 2002, 30: 1747-1752. PMID: 12163787, DOI: 10.1097/00003246-200208000-00012.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAgedAPACHEBronchiectasisBronchogenic CystFemaleHumansLungLung ComplianceLung InjuryMaleMiddle AgedPneumothoraxPredictive Value of TestsPrevalenceRespiratory Distress SyndromeRetrospective StudiesSeverity of Illness IndexStatistics as TopicSurvival AnalysisSwitzerlandTime FactorsTomography, X-Ray ComputedTreatment FailureVentilators, MechanicalConceptsSevere acute respiratory distress syndromeAcute respiratory distress syndromeRespiratory distress syndromeMechanical ventilationAir cystsDistress syndromeHigh end-inspiratory pressuresVentilator-induced lung damageRetrospective observational studyPresence of pneumothoraxEnd-inspiratory pressureHigh inspiratory pressuresSeverity of changesNondependent areasLung damageInspiratory pressureMinute ventilationTomographic scanOdds ratioTomographic scanningObservational studyLung fieldsTidal volumeBronchial divisionsAbnormal parenchyma