2021
Factor VIII inhibitor bypass activity (FEIBA) for the reduction of transfusion in cardiac surgery: a randomized, double-blind, placebo-controlled, pilot trial
Sera VA, Stevens AE, Song HK, Rodriguez VM, Tibayan FA, Treggiari MM. Factor VIII inhibitor bypass activity (FEIBA) for the reduction of transfusion in cardiac surgery: a randomized, double-blind, placebo-controlled, pilot trial. Pilot And Feasibility Studies 2021, 7: 137. PMID: 34215339, PMCID: PMC8252226, DOI: 10.1186/s40814-021-00873-5.Peer-Reviewed Original ResearchFactor Eight Inhibitor Bypassing ActivityCardiac surgeryPilot trialTransfusion requirementsRescue therapyLarge trialsProtocol adherenceBlood productsHigh-risk cardiac surgeryProthrombin complex concentrate administrationPlacebo-controlled pilot trialFactor VIII inhibitor bypass activityLarge pivotal trialsReduction of transfusionBlood product transfusionEnd of CPBTertiary referral hospitalHypothermic circulatory arrestTermination of CPBPost-cardiopulmonary bypassProthrombin complex concentrateBlinded administrationProduct transfusionResultsTwenty patientsStudy drug
2015
Randomized Pilot Trial of Intensive Management of Blood Pressure or Volume Expansion in Subarachnoid Hemorrhage (IMPROVES)
Togashi K, Joffe AM, Sekhar L, Kim L, Lam A, Yanez D, Broeckel-Elrod JA, Moore A, Deem S, Khandelwal N, Souter MJ, Treggiari MM. Randomized Pilot Trial of Intensive Management of Blood Pressure or Volume Expansion in Subarachnoid Hemorrhage (IMPROVES). Neurosurgery 2015, 76: 125-135. PMID: 25549192, DOI: 10.1227/neu.0000000000000592.Peer-Reviewed Original ResearchConceptsRankin Scale scoreCerebral ischemiaSubarachnoid hemorrhageCBP groupBlood pressureLarge trialsPilot trialScale scoreOptimal blood pressure managementSystolic blood pressure differenceModified Rankin Scale scoreBlood pressure manipulationIntravenous fluid intakeWorse neurobehavioral outcomesBlood pressure managementBlood pressure differenceDelayed Cerebral IschemiaRandomized pilot trialPulmonary complicationsAdverse eventsDischarge dispositionHemodynamic managementStudy endpointPatient populationProtocol adherence
2007
Approach to eradication of initial Pseudomonas aeruginosa infection in children with cystic fibrosis
Treggiari MM, Rosenfeld M, Retsch‐Bogart G, Gibson R, Ramsey B. Approach to eradication of initial Pseudomonas aeruginosa infection in children with cystic fibrosis. Pediatric Pulmonology 2007, 42: 751-756. PMID: 17647287, DOI: 10.1002/ppul.20665.Peer-Reviewed Original ResearchConceptsAnti-pseudomonal antibioticsCystic fibrosisEarly interventionInitial Pseudomonas aeruginosa infectionSafe treatment regimenObstructive lung diseasePseudomonas aeruginosa infectionChronic endobronchial infectionLower airwaysTreatment regimenEndobronchial infectionClinical benefitLarge trialsLung diseaseAeruginosa infectionPA isolatesYoung childrenPa acquisitionFibrosisInfectionChildrenPrimary causePseudomonas aeruginosaWindow of opportunityEradication