2012
Mortality and long-term functional outcome associated with intracranial pressure after traumatic brain injury
Badri S, Chen J, Barber J, Temkin NR, Dikmen SS, Chesnut RM, Deem S, Yanez ND, Treggiari MM. Mortality and long-term functional outcome associated with intracranial pressure after traumatic brain injury. Intensive Care Medicine 2012, 38: 1800-1809. PMID: 23011528, DOI: 10.1007/s00134-012-2655-4.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryAverage intracranial pressureIntracranial pressureFunctional statusTBI patientsBrain injuryNeuropsychological functioningAbbreviated Injury Scale headLong-term functional outcomeSevere traumatic brain injuryAdult TBI patientsInjury scale headGlasgow Coma ScoreSevere TBI patientsPrimary endpointComa ScoreComposite endpointIndependent predictorsFunctional outcomeOdds ratioMultivariable regressionNeuropsychological outcomesNeuropsychological testingPatientsNeuropsychological function
2011
Open-Label Randomized Trial of the Safety and Efficacy of a Single Dose Conivaptan to Raise Serum Sodium in Patients with Traumatic Brain Injury
Galton C, Deem S, Yanez ND, Souter M, Chesnut R, Dagal A, Treggiari M. Open-Label Randomized Trial of the Safety and Efficacy of a Single Dose Conivaptan to Raise Serum Sodium in Patients with Traumatic Brain Injury. Neurocritical Care 2011, 14: 354-360. PMID: 21409494, DOI: 10.1007/s12028-011-9525-8.Peer-Reviewed Original ResearchConceptsTraumatic brain injurySevere traumatic brain injuryUsual care groupIntracranial pressureSerum sodiumAdverse eventsUrine outputCare groupSodium loadBrain injuryDrug-related serious adverse eventsEffects of conivaptanLabel Randomized TrialNon-hyponatremic patientsSerum sodium increaseSerious adverse eventsTreatment of hyponatremiaSodium increasesMethodsOpen-labelNormonatremic patientsPrimary endpointResultsTen patientsSecondary endpointsUsual careMean sodium
2007
Role of intracranial pressure values and patterns in predicting outcome in traumatic brain injury: a systematic review
Treggiari MM, Schutz N, Yanez ND, Romand JA. Role of intracranial pressure values and patterns in predicting outcome in traumatic brain injury: a systematic review. Neurocritical Care 2007, 6: 104-112. PMID: 17522793, DOI: 10.1007/s12028-007-0012-1.Peer-Reviewed Original ResearchConceptsNeurological outcomePoor neurological outcomeIntracranial pressureICP valuesOdds ratioICP patternsLong-term outcomesNormal intracranial pressureSummary odds ratiosTraumatic brain injuryAbsolute ICP valuesIntracranial pressure valuesRegistry searchMethodsSystematic reviewProspective studyBrain injuryRelative riskICP monitoringMethodological qualityMAIN OUTCOMEReference listsSystematic reviewLogistic regressionICP 20Outcomes