2011
Comparative Efficacy and Safety of 4 Randomized Regimens to Treat Early Pseudomonas aeruginosa Infection in Children With Cystic Fibrosis
Treggiari MM, Retsch-Bogart G, Mayer-Hamblett N, Khan U, Kulich M, Kronmal R, Williams J, Hiatt P, Gibson RL, Spencer T, Orenstein D, Chatfield BA, Froh DK, Burns JL, Rosenfeld M, Ramsey BW, Investigators F. Comparative Efficacy and Safety of 4 Randomized Regimens to Treat Early Pseudomonas aeruginosa Infection in Children With Cystic Fibrosis. JAMA Pediatrics 2011, 165: 847-856. PMID: 21893650, PMCID: PMC3991697, DOI: 10.1001/archpediatrics.2011.136.Peer-Reviewed Original ResearchConceptsPseudomonas aeruginosa infectionCulture-based therapyCulture-based groupsCystic fibrosisAeruginosa infectionEarly Pseudomonas aeruginosa infectionTobramycin inhalation solutionPrimary end pointRate of exacerbationsExacerbation rateIntravenous antibioticsOral ciprofloxacinOral placeboAntibiotic regimensPulmonary exacerbationsAdverse eventsTreat analysisMulticenter trialAntipseudomonal treatmentInhalation solutionOdds ratioComparative efficacyPlaceboEnd pointFibrosis
2007
Approach to eradication of initial Pseudomonas aeruginosa infection in children with cystic fibrosis
Treggiari MM, Rosenfeld M, Retsch‐Bogart G, Gibson R, Ramsey B. Approach to eradication of initial Pseudomonas aeruginosa infection in children with cystic fibrosis. Pediatric Pulmonology 2007, 42: 751-756. PMID: 17647287, DOI: 10.1002/ppul.20665.Peer-Reviewed Original ResearchConceptsAnti-pseudomonal antibioticsCystic fibrosisEarly interventionInitial Pseudomonas aeruginosa infectionSafe treatment regimenObstructive lung diseasePseudomonas aeruginosa infectionChronic endobronchial infectionLower airwaysTreatment regimenEndobronchial infectionClinical benefitLarge trialsLung diseaseAeruginosa infectionPA isolatesYoung childrenPa acquisitionFibrosisInfectionChildrenPrimary causePseudomonas aeruginosaWindow of opportunityEradication