2022
Pharmacokinetics and Tolerability of Intraperitoneal Chloroprocaine After Fetal Extraction in Women Undergoing Cesarean Delivery
Togioka BM, Zarnegarnia Y, Bleyle LA, Koop D, Brookfield K, Yanez ND, Treggiari MM. Pharmacokinetics and Tolerability of Intraperitoneal Chloroprocaine After Fetal Extraction in Women Undergoing Cesarean Delivery. Anesthesia & Analgesia 2022, 135: 777-786. PMID: 35544759, DOI: 10.1213/ane.0000000000006064.Peer-Reviewed Original ResearchConceptsLocal anesthetic systemic toxicityPeak plasma concentrationCesarean deliveryPlasma concentrationsSystemic toxicityIntraperitoneal administrationFetal extractionMultiple-dose escalation studyPatient drug exposureMaternal blood samplesMaximum plasma concentrationRoute of administrationYears of ageClinical tolerabilityEscalation studySpinal anesthesiaUterine closureNeuraxial anesthesiaClinical symptomsDrug exposureClinical signsWomen 18Prospective assessmentBlood samplesPharmacokinetic profile
2016
Randomized Pilot Trial of Two Modified Endotracheal Tubes To Prevent Ventilator-associated Pneumonia
Deem S, Yanez D, Sissons-Ross L, Broeckel JA, Daniel S, Treggiari M. Randomized Pilot Trial of Two Modified Endotracheal Tubes To Prevent Ventilator-associated Pneumonia. Annals Of The American Thoracic Society 2016, 13: 72-80. PMID: 26523433, PMCID: PMC4722846, DOI: 10.1513/annalsats.201506-346oc.Peer-Reviewed Original ResearchConceptsEndotracheal tubeTracheal colonizationChest radiograph criteriaOccurrence of VAPPrevention of VAPCoprimary end pointsSerious adverse eventsInstitutional review board approvalEmergency endotracheal intubationStandard endotracheal tubeMajority of intubationsReview board approvalModified Endotracheal TubeSafety concernsAdverse eventsVAP preventionEndotracheal intubationSubglottic secretionsEmergency intubationClinical trialsClinical signsNosocomial infectionsPilot trialStudy groupHospital setting