2011
Hemodynamic Management of Subarachnoid Hemorrhage
Treggiari MM, Participants in the International Multi-disciplinary Consensus Conference on the Critical Care Management of Subarachnoid Hemorrhage. Hemodynamic Management of Subarachnoid Hemorrhage. Neurocritical Care 2011, 15: 329. PMID: 21786046, DOI: 10.1007/s12028-011-9589-5.Peer-Reviewed Original ResearchConceptsHemodynamic augmentation therapyHemodynamic augmentationUnsecured aneurysmsAugmentation therapySubarachnoid hemorrhageHigher cerebral blood flowBlood pressure augmentationBlood pressure managementCerebral blood flowElectronic literature searchEnglish language papersInotropic therapyCerebral ischemiaHemodynamic managementVolume statusInotropic agentsStandard treatmentSymptom reversalAneurysmal ruptureEligible reportsBlood flowSide effectsPatientsPressure augmentationIncremental risk
2009
Which H is the most important in triple-H therapy for cerebral vasospasm?
Treggiari MM, Deem S. Which H is the most important in triple-H therapy for cerebral vasospasm? Current Opinion In Critical Care 2009, 15: 83-86. PMID: 19276798, DOI: 10.1097/mcc.0b013e32832922d1.Peer-Reviewed Original ResearchConceptsCerebral vasospasmSubarachnoid hemorrhageCirculatory volume expansionNew randomized trialsCerebral blood flowHemodynamic managementRandomized trialsHemodynamic variablesHypervolemic hemodilutionRegistry databaseBlood flowPaucity of informationVasospasmPhysiologic dataHemorrhagePhysiological studiesLow levelsHypertensionComplicationsHemodilutionTherapyRecent literatureTrials
2008
Tezosentan normalizes hepatomesenteric perfusion in a porcine model of cardiac tamponade
ÅNEMAN A, TREGGIARI MM, BURGENER D, LAESSER M, STRASSER S, HADENGUE A. Tezosentan normalizes hepatomesenteric perfusion in a porcine model of cardiac tamponade. Acta Anaesthesiologica Scandinavica 2008, 53: 203-209. PMID: 19094177, DOI: 10.1111/j.1399-6576.2008.01834.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarbon DioxideCardiac Output, LowCardiac TamponadeDrug Evaluation, PreclinicalEndothelin Receptor AntagonistsEndothelin-1FemaleLactatesLiver CirculationMaleModels, AnimalOxygenOxygen ConsumptionPyridinesSplanchnic CirculationSus scrofaTetrazolesVascular ResistanceVasoconstrictionConceptsLaser Doppler flowMesenteric oxygen deliveryLow CO stateBaseline valuesCardiac tamponadeOxygen deliveryBlood flowPorcine modelPortal venous blood flowHepatic artery blood flowLow cardiac output stateET-1 blockadeMesenteric oxygen extractionMesenteric vascular resistanceArtery blood flowCardiac output stateNormal saline vehicleVenous blood flowMesenteric vasoconstrictionPortal pressureSplanchnic hypoperfusionVascular resistanceHepatic arterialEndothelin-1Liver protectionEffects of Anemia and Hypotension on Porcine Optic Nerve Blood Flow and Oxygen Delivery
Lee LA, Deem S, Glenny RW, Townsend I, Moulding J, An D, Treggiari MM, Lam A. Effects of Anemia and Hypotension on Porcine Optic Nerve Blood Flow and Oxygen Delivery. Anesthesiology 2008, 108: 864-872. PMID: 18431122, DOI: 10.1097/aln.0b013e31816c8a30.Peer-Reviewed Original ResearchConceptsCerebral blood flowOptic nerve blood flowNerve blood flowBlood flowCerebral DO2Venous congestionHypovolemic hypotensionOxygen deliveryPerioperative ischemic optic neuropathyCompensatory mechanismsStable cerebral blood flowIschemic optic neuropathyMajor surgical proceduresEffect of anemiaConditions of hypotensionSignificant reductionOptic neuropathyHypotensionSurgical proceduresControl animalsAnemiaFarm-raised pigsPhysiologic perturbationsDO2Significant increase
2002
Effect of increasing norepinephrine dosage on regional blood flow in a porcine model of endotoxin shock*
Treggiari MM, Romand JA, Burgener D, Suter PM, Aneman A. Effect of increasing norepinephrine dosage on regional blood flow in a porcine model of endotoxin shock*. Critical Care Medicine 2002, 30: 1334-1339. PMID: 12072691, DOI: 10.1097/00003246-200206000-00032.Peer-Reviewed Original ResearchConceptsMean arterial pressureArterial pressureCardiac outputRenal arteryEndotoxic shockPortal veinBlood flowPorcine modelPortal vein blood flowAdministration of norepinephrineEndotoxic shock modelSystemic oxygen extractionVein blood flowEnhanced cardiac outputLaser Doppler flowmetryRegional blood flowAcute endotoxic shock modelAcute interventional studyAnimal research laboratoryEndotoxemic controlsJejunal tonometryNorepinephrine dosageRenal perfusionAcute modelInterventional study