2021
A Double-Blind, Randomized, Placebo-Controlled Trial of Soluble Epoxide Hydrolase Inhibition in Patients with Aneurysmal Subarachnoid Hemorrhage
Martini RP, Siler D, Cetas J, Alkayed NJ, Allen E, Treggiari MM. A Double-Blind, Randomized, Placebo-Controlled Trial of Soluble Epoxide Hydrolase Inhibition in Patients with Aneurysmal Subarachnoid Hemorrhage. Neurocritical Care 2021, 36: 905-915. PMID: 34873674, DOI: 10.1007/s12028-021-01398-8.Peer-Reviewed Original ResearchConceptsSoluble epoxide hydrolaseAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageDHET ratiosEnd pointDay 7Day 10Primary study end pointSoluble epoxide hydrolase inhibitionCSF inflammatory cytokinesEET/DHET ratiosIncidence of DCIPrevention of DCITertiary end pointSecondary end pointsStudy end pointCerebral blood flowLength of stayEndothelial injury biomarkersEpoxide hydrolase inhibitionNeurovascular inflammationResultsTen patientsStudy drugAdverse eventsCytokine levels
2010
Current Practices of Triple-H Prophylaxis and Therapy in Patients with Subarachnoid Hemorrhage
Meyer R, Deem S, David Yanez N, Souter M, Lam A, Treggiari MM. Current Practices of Triple-H Prophylaxis and Therapy in Patients with Subarachnoid Hemorrhage. Neurocritical Care 2010, 14: 24-36. PMID: 20838932, DOI: 10.1007/s12028-010-9437-z.Peer-Reviewed Original ResearchConceptsNeurointensive care unitSubarachnoid hemorrhagePercent of respondentsProphylactic hypervolemiaHemodilution therapySymptomatic vasospasmCerebral vasospasmDedicated neurointensive care unitsDiagnostic approachMean arterial pressureCentral venous cathetersSystolic blood pressureEvidence of vasospasmAneurysmal subarachnoid hemorrhageNeurocritical Care SocietyTarget of therapyBackgroundMedical managementLonger ICULack of evidenceVenous cathetersArterial pressureBlood pressureCare unitHalf of respondentsPressure titration
2003
Cervical Sympathetic Block to Reverse Delayed Ischemic Neurological Deficits After Aneurysmal Subarachnoid Hemorrhage
Treggiari MM, Romand JA, Martin JB, Reverdin A, Rüfenacht DA, de Tribolet N. Cervical Sympathetic Block to Reverse Delayed Ischemic Neurological Deficits After Aneurysmal Subarachnoid Hemorrhage. Stroke 2003, 34: 961-966. PMID: 12649526, DOI: 10.1161/01.str.0000060893.72098.80.Peer-Reviewed Original ResearchConceptsCervical sympathetic blockAneurysmal subarachnoid hemorrhageSympathetic blockCerebral perfusionNeurological statusCerebral vasospasmSubarachnoid hemorrhageMaximal medical treatmentCervical sympathetic chainIschemic neurological deficitsSuperior cervical ganglionConfirmatory angiographyHorner's signIschemic deficitsLocoregional treatmentNeurological deficitsSevere vasospasmStandard therapyCerebral angiographyConsecutive patientsSympathetic chainLocoregional anesthesiaCervical ganglionInitial hemorrhageModerate symptoms