2024
Tumor response assessment in hepatocellular carcinoma treated with immunotherapy: imaging biomarkers for clinical decision-making
Sobirey R, Matuschewski N, Gross M, Lin M, Kao T, Kasolowsky V, Strazzabosco M, Stein S, Savic L, Gebauer B, Jaffe A, Duncan J, Madoff D, Chapiro J. Tumor response assessment in hepatocellular carcinoma treated with immunotherapy: imaging biomarkers for clinical decision-making. European Radiology 2024, 1-11. PMID: 39033181, DOI: 10.1007/s00330-024-10955-6.Peer-Reviewed Original ResearchMedian overall survivalTumor response criteriaTumor response assessmentHepatocellular carcinoma patientsHepatocellular carcinomaTumor responseOverall survivalResponse criteriaResponse assessmentNon-respondersPoorer median overall survivalPrediction of tumor responsePredictive valueHepatocellular carcinoma immunotherapyDisease controlPrognostic of survivalClinical baseline parametersLog-rank testKaplan-Meier curvesMultivariate Cox regressionPredicting overall survivalCox regression modelsSurvival benefitStratify patientsMRI pre-
2023
Intraprocedural C‐arm dual‐phase cone‐beam enhancement patterns correlate with tumor absorbed dose after radioembolization
Bastiaannet R, Lin M, Frey E, de Jong H. Intraprocedural C‐arm dual‐phase cone‐beam enhancement patterns correlate with tumor absorbed dose after radioembolization. Medical Physics 2023, 51: 3045-3052. PMID: 38064591, PMCID: PMC10994751, DOI: 10.1002/mp.16882.Peer-Reviewed Original ResearchContrast-enhanced cone-beam CTHepatocellular carcinomaPET/CT scansNon-tumor liver tissuesPersonalized treatment planningIntra-procedural imagingBlood flow patternsPretreatment tumorRetrospective studyLimits of agreementTumor responseBland-Altman analysisClinical trialsTumor doseCT scanEnhancement patternHepatic vasculatureHCC tumorsCatheter positionTumor tissueLiver tissueTumorsHepatic radioembolizationPatientsDose
2022
Three-Dimensional Quantitative Tumor Response and Survival Analysis of Hepatocellular Carcinoma Patients Who Failed Initial Transarterial Chemoembolization: Repeat or Switch Treatment?
Zhao Y, Haroun R, Sahu S, Schernthaner R, Smolka S, Lin M, Hong K, Georgiades C, Duran R. Three-Dimensional Quantitative Tumor Response and Survival Analysis of Hepatocellular Carcinoma Patients Who Failed Initial Transarterial Chemoembolization: Repeat or Switch Treatment? Cancers 2022, 14: 3615. PMID: 35892874, PMCID: PMC9329887, DOI: 10.3390/cancers14153615.Peer-Reviewed Original ResearchOverall survivalSecond TACEHepatocellular carcinoma patientsFirst TACECarcinoma patientsTumor responseInitial transarterial chemoembolizationMedian overall survivalTransarterial chemoembolization sessionsKaplan-Meier methodLonger overall survivalLog-rank testChemoembolization sessionsConsecutive patientsTransarterial chemoembolizationSurvival outcomesHCC patientsTreatment responseTumor enhancementPatientsSurvival analysisTACEEuropean AssociationRespondersSignificant differences
2021
Lipiodol Deposition and Washout in Primary and Metastatic Liver Tumors After Chemoembolization
Nezami N, VAN Breugel JMM, Konstantinidis M, Chapiro J, Savic LJ, Miszczuk MA, Rexha I, Lin M, Hong K, Georgiades C. Lipiodol Deposition and Washout in Primary and Metastatic Liver Tumors After Chemoembolization. In Vivo 2021, 35: 3261-3270. PMID: 34697157, PMCID: PMC8627740, DOI: 10.21873/invivo.12621.Peer-Reviewed Original ResearchConceptsConventional trans-arterial chemoembolizationTrans-arterial chemoembolizationNeuroendocrine tumorsColorectal carcinomaIntrahepatic cholangiocarcinomaLipiodol depositionWashout rateContrast-enhanced magnetic resonanceMetastatic liver tumorsColorectal carcinoma tumorsLiver metastasesHepatic metastasesTumor responseTarget lesionsRetrospective analysisLiver tumorsSmall tumorsChemoembolizationCarcinoma tumorsTumorsExponential washoutCarcinomaTomography imagingWashoutCholangiocarcinomaLipiodol as an intra-procedural imaging biomarker for liver tumor response to transarterial chemoembolization: Post-hoc analysis of a prospective clinical trial
Letzen BS, Malpani R, Miszczuk M, de Ruiter QMB, Petty CW, Rexha I, Nezami N, Laage-Gaupp F, Lin M, Schlachter TR, Chapiro J. Lipiodol as an intra-procedural imaging biomarker for liver tumor response to transarterial chemoembolization: Post-hoc analysis of a prospective clinical trial. Clinical Imaging 2021, 78: 194-200. PMID: 34022765, PMCID: PMC8364875, DOI: 10.1016/j.clinimag.2021.05.007.Peer-Reviewed Original ResearchConceptsConventional trans-arterial chemoembolizationMedian overall survivalProspective clinical trialsLipiodol depositionTumor responsePredictive biomarkersClinical trialsModified Response Evaluation CriteriaPost-TACE CTResponse Evaluation CriteriaMetastatic liver cancerKaplan-Meier analysisTrans-arterial chemoembolizationTumor response criteriaLiver tumor responsePrediction of survivalSelective drug targetingArterial embolizationLiver metastasesOverall survivalBland-Altman plotsTransarterial chemoembolizationPortal veinTumor respondersHepatocellular carcinoma
2020
Automated feature quantification of Lipiodol as imaging biomarker to predict therapeutic efficacy of conventional transarterial chemoembolization of liver cancer
Stark S, Wang C, Savic LJ, Letzen B, Schobert I, Miszczuk M, Murali N, Oestmann P, Gebauer B, Lin M, Duncan J, Schlachter T, Chapiro J. Automated feature quantification of Lipiodol as imaging biomarker to predict therapeutic efficacy of conventional transarterial chemoembolization of liver cancer. Scientific Reports 2020, 10: 18026. PMID: 33093524, PMCID: PMC7582153, DOI: 10.1038/s41598-020-75120-7.Peer-Reviewed Original ResearchConceptsConventional transarterial chemoembolizationLipiodol depositionTransarterial chemoembolizationLiver cancerPeripheral depositionLipiodol depositsTherapeutic efficacyNecrotic tumor areasBaseline MRITherapy optionsTumor responseTreatment responseTumor volumeLiver lesionsLipiodolH postTumor areaH-CTHounsfield unitsBiomarkersChemoembolizationHigh rateTumorsCancerImproved response
2019
Quantitative Imaging Biomarkers for 90Y Distribution on Bremsstrahlung SPECT After Resin-Based Radioembolization
Schobert I, Chapiro J, Nezami N, Hamm CA, Gebauer B, Lin M, Pollak J, Saperstein L, Schlachter T, Savic LJ. Quantitative Imaging Biomarkers for 90Y Distribution on Bremsstrahlung SPECT After Resin-Based Radioembolization. Journal Of Nuclear Medicine 2019, 60: 1066-1072. PMID: 30655331, PMCID: PMC6681698, DOI: 10.2967/jnumed.118.219691.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngiographyBiomarkersCarcinoma, HepatocellularEmbolization, TherapeuticFeasibility StudiesFemaleHumansImaging, Three-DimensionalLiverLiver NeoplasmsMagnetic Resonance ImagingMaleMicrospheresMiddle AgedMultimodal ImagingPrognosisRegression AnalysisRetrospective StudiesTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedTreatment OutcomeYttrium RadioisotopesConceptsNon-HCC patientsTransarterial radioembolizationHepatocellular carcinomaBaseline imagingTumor responseTumor volumeChild-Pugh class B patientsBaseline imaging featuresClass B patientsNormal liver ratiosTotal tumor volumeSPECT/CTContrast-enhanced MRIQuantitative European AssociationMultiphasic contrast-enhanced MRIInstitutional review boardHigh TNRPreprocedural MRIChild-PughB patientsLiver criteriaTumor burdenClinical parametersHepatic malignanciesRetrospective study
2016
3:36 PMAbstract No. 53 Which response criteria can predict early tumor response in CT image in hepatocellular carcinoma patients treated with TACE: RECIST, mRECIST, EASL or qEASL?
Zhao Y, Sahu S, Bai W, Schernthaner R, Duran R, Chapiro J, Yin Z, Lin M, Han G, Geschwind J. 3:36 PMAbstract No. 53 Which response criteria can predict early tumor response in CT image in hepatocellular carcinoma patients treated with TACE: RECIST, mRECIST, EASL or qEASL? Journal Of Vascular And Interventional Radiology 2016, 27: s28. DOI: 10.1016/j.jvir.2015.12.084.Peer-Reviewed Original Research
2015
Intraprocedural 3D Quantification of Lipiodol Deposition on Cone-Beam CT Predicts Tumor Response After Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma
Wang Z, Chen R, Duran R, Zhao Y, Yenokyan G, Chapiro J, Schernthaner R, Radaelli A, Lin M, Geschwind JF. Intraprocedural 3D Quantification of Lipiodol Deposition on Cone-Beam CT Predicts Tumor Response After Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma. CardioVascular And Interventional Radiology 2015, 38: 1548-1556. PMID: 26001366, PMCID: PMC4651808, DOI: 10.1007/s00270-015-1129-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoma, HepatocellularChemoembolization, TherapeuticCone-Beam Computed TomographyContrast MediaEthiodized OilFemaleFollow-Up StudiesHumansImage EnhancementImaging, Three-DimensionalLiverLiver NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesTreatment OutcomeConceptsLipiodol depositionConventional transarterial chemoembolizationTumor responseOverall tumor volumeTumor volumeCE-MRIHepatocellular carcinomaTransarterial chemoembolizationTumor necrosisContrast-enhanced magnetic resonance imagingNecrotic tumour volumeResponse Evaluation CriteriaT-testMagnetic resonance imagingStudent's t-testMethodsThis IRBTarget lesionsRetrospective analysisSolid tumorsResonance imagingSpearman rank-order correlationPatientsCone-beam CTCBCTChemoembolization8:00 AM, Abstract No. 260 Volumetric contrast patterns on intraprocedural cone-beam CT predicts tumor response: preliminary results in a prospective trial of HCC patients treated with DEBDOX-M1 bead TACE
Sahu S, Duran R, Schernthaner R, Sohn J, Reyes D, Lin M, Geschwind J. 8:00 AM, Abstract No. 260 Volumetric contrast patterns on intraprocedural cone-beam CT predicts tumor response: preliminary results in a prospective trial of HCC patients treated with DEBDOX-M1 bead TACE. Journal Of Vascular And Interventional Radiology 2015, 26: s119. DOI: 10.1016/j.jvir.2014.12.323.Peer-Reviewed Original ResearchEarly survival prediction after intra-arterial therapies: a 3D quantitative MRI assessment of tumour response after TACE or radioembolization of colorectal cancer metastases to the liver
Chapiro J, Duran R, Lin M, Schernthaner R, Lesage D, Wang Z, Savic LJ, Geschwind JF. Early survival prediction after intra-arterial therapies: a 3D quantitative MRI assessment of tumour response after TACE or radioembolization of colorectal cancer metastases to the liver. European Radiology 2015, 25: 1993-2003. PMID: 25636420, PMCID: PMC4458393, DOI: 10.1007/s00330-015-3595-5.Peer-Reviewed Original ResearchConceptsIntra-arterial therapyColorectal liver metastasesTransarterial chemoembolizationPatient survivalHazard ratioLiver metastasesOverall survivalResponse assessmentVolumetric tumour response assessmentCox proportional hazard ratiosMethodsThis retrospective analysisProportional hazard ratiosKaplan-Meier analysisColorectal cancer metastasisTumor response assessmentTumor analysisEarly survival predictionQuantitative MRI assessmentMRI assessmentTumor responseLesion volumeRetrospective analysisMultivariate analysisPatientsPredictive role
2014
Identifying Staging Markers for Hepatocellular Carcinoma before Transarterial Chemoembolization: Comparison of Three-dimensional Quantitative versus Non–three-dimensional Imaging Markers
Chapiro J, Duran R, Lin M, Schernthaner RE, Wang Z, Gorodetski B, Geschwind JF. Identifying Staging Markers for Hepatocellular Carcinoma before Transarterial Chemoembolization: Comparison of Three-dimensional Quantitative versus Non–three-dimensional Imaging Markers. Radiology 2014, 275: 438-47. PMID: 25531387, PMCID: PMC4409467, DOI: 10.1148/radiol.14141180.Peer-Reviewed Original ResearchConceptsUnresectable hepatocellular carcinomaTransarterial chemoembolizationHepatocellular carcinomaTumor diameterHazard ratioTumor responseTumor volumeResponse rateCox proportional hazard ratiosStaging markersTumor response rateProportional hazard ratiosResponse Evaluation CriteriaSurvival of patientsKaplan-Meier analysisSingle-institution analysisBaseline magnetic resonance imagesHigh response rateInstitutional review boardOverall survivalLiver (EASL) guidelinesPatient cohortImaging markerRadiologic measurementsLarge lesionsTransarterial chemoembolization in soft-tissue sarcoma metastases to the liver – The use of imaging biomarkers as predictors of patient survival
Chapiro J, Duran R, Lin M, Mungo B, Schlachter T, Schernthaner R, Gorodetski B, Wang Z, Geschwind JF. Transarterial chemoembolization in soft-tissue sarcoma metastases to the liver – The use of imaging biomarkers as predictors of patient survival. European Journal Of Radiology 2014, 84: 424-430. PMID: 25542065, PMCID: PMC4315698, DOI: 10.1016/j.ejrad.2014.11.034.Peer-Reviewed Original ResearchConceptsMetastatic soft tissue sarcomaProgression-free survivalConventional transarterial chemoembolizationSoft tissue sarcomasOverall survivalTumor responseTransarterial chemoembolizationPatient survivalSafety profileCox proportional hazard ratio analysisProportional hazard ratio analysisSoft tissue sarcoma metastasisMedian overall survivalSalvage therapy optionsHazard ratio analysisReliable clinical dataSize-based criteriaEASL guidelinesModified RECISTIntraarterial therapySarcoma metastasisSurvival outcomesGrade IIIKaplan-MeierTherapy optionsAssessing tumor response after loco-regional liver cancer therapies: the role of 3D MRI
Chapiro J, Lin M, Duran R, Schernthaner RE, Geschwind JF. Assessing tumor response after loco-regional liver cancer therapies: the role of 3D MRI. Expert Review Of Anticancer Therapy 2014, 15: 199-205. PMID: 25371052, PMCID: PMC4304995, DOI: 10.1586/14737140.2015.978861.Peer-Reviewed Original ResearchConceptsTumor responseResponse Evaluation CriteriaTumor response criteriaMajor clinical interestLiver cancer therapyLiver cancer lesionsClinical evidenceIntraarterial therapyCancer lesionsSolid tumorsResponse criteriaAnatomic methodsClinical interestImaging modalitiesCancer therapyTumor analysisTherapyMRILesionsTumorsUveal Melanoma Metastatic to the Liver: The Role of Quantitative Volumetric Contrast-Enhanced MR Imaging in the Assessment of Early Tumor Response after Transarterial Chemoembolization
Duran R, Chapiro J, Frangakis C, Lin M, Schlachter TR, Schernthaner RE, Wang Z, Savic LJ, Tacher V, Kamel IR, Geschwind JF. Uveal Melanoma Metastatic to the Liver: The Role of Quantitative Volumetric Contrast-Enhanced MR Imaging in the Assessment of Early Tumor Response after Transarterial Chemoembolization. Translational Oncology 2014, 7: 447-455. PMID: 24953419, PMCID: PMC4202794, DOI: 10.1016/j.tranon.2014.05.004.Peer-Reviewed Original ResearchFirst transarterial chemoembolizationEarly tumor responseTransarterial chemoembolizationWorld Health OrganizationOverall survivalTumor responseTarget lesionsTumor volumeTumor enhancementUveal melanomaContrast-enhanced magnetic resonance imagingNon-target lesionsUveal melanoma metastaticMedian overall survivalResponse Evaluation CriteriaKaplan-Meier methodLog-rank testMetastatic uveal melanomaMagnetic resonance imagingMelanoma metastaticSurrogate biomarkerSolid tumorsResonance imagingResponse criteriaLesions1:39 PM Abstract No. 241 Quantitative 3D volumetric assessment of tumor response after intra-arterial therapy of colorectal cancer metastases to the liver – a new surrogate marker for survival
Chapiro J, Duran R, Lin M, Charu V, Wang Z, Tacher V, Lesage D, Geschwind J. 1:39 PM Abstract No. 241 Quantitative 3D volumetric assessment of tumor response after intra-arterial therapy of colorectal cancer metastases to the liver – a new surrogate marker for survival. Journal Of Vascular And Interventional Radiology 2014, 25: s113. DOI: 10.1016/j.jvir.2013.12.311.Peer-Reviewed Original Research2:42 PM Abstract No. 45 Uveal melanoma metastatic to the liver: the role of quantitative and functional MR imaging in the assessment of early tumor response after TACE
Duran R, Chapiro J, Lin M, Frangakis C, Lesage D, Schlachter T, Tacher V, Wang Z, Geschwind J. 2:42 PM Abstract No. 45 Uveal melanoma metastatic to the liver: the role of quantitative and functional MR imaging in the assessment of early tumor response after TACE. Journal Of Vascular And Interventional Radiology 2014, 25: s27. DOI: 10.1016/j.jvir.2013.12.063.Peer-Reviewed Original Research
2012
Quantitative and Volumetric European Association for the Study of the Liver and Response Evaluation Criteria in Solid Tumors Measurements: Feasibility of a Semiautomated Software Method to Assess Tumor Response after Transcatheter Arterial Chemoembolization
Lin M, Pellerin O, Bhagat N, Rao P, Loffroy R, Ardon R, Mory B, Reyes D, Geschwind J. Quantitative and Volumetric European Association for the Study of the Liver and Response Evaluation Criteria in Solid Tumors Measurements: Feasibility of a Semiautomated Software Method to Assess Tumor Response after Transcatheter Arterial Chemoembolization. Journal Of Vascular And Interventional Radiology 2012, 23: 1629-1637. PMID: 23177109, PMCID: PMC3579576, DOI: 10.1016/j.jvir.2012.08.028.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic AgentsCarcinoma, HepatocellularChemoembolization, TherapeuticFemaleHumansImaging, Three-DimensionalLiver NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedPattern Recognition, AutomatedReproducibility of ResultsSensitivity and SpecificitySoftwareSoftware ValidationTreatment OutcomeTumor BurdenConceptsTranscatheter arterial chemoembolizationArterial chemoembolizationHepatocellular carcinomaDrug-eluting bead transcatheter arterial chemoembolizationSingle-institution prospective studyResponse Evaluation CriteriaContrast-enhanced magnetic resonanceHepatic tumor volumeSolid tumor measurementsThree-dimensional volumetric assessmentMagnetic resonanceIntraarterial therapyProspective studyTumor responseClinical correlationTumor measurementsTumor volumeTumor enhancementInterventional radiologistsPatientsVolumetric assessmentChemoembolizationEuropean AssociationVolume assessmentVoxel basisIntraprocedural C-Arm Dual-Phase Cone-Beam CT: Can It Be Used to Predict Short-term Response to TACE with Drug-eluting Beads in Patients with Hepatocellular Carcinoma?
Loffroy R, Lin M, Yenokyan G, Rao PP, Bhagat N, Noordhoek N, Radaelli A, Blijd J, Liapi E, Geschwind JF. Intraprocedural C-Arm Dual-Phase Cone-Beam CT: Can It Be Used to Predict Short-term Response to TACE with Drug-eluting Beads in Patients with Hepatocellular Carcinoma? Radiology 2012, 266: 636-648. PMID: 23143027, PMCID: PMC3558876, DOI: 10.1148/radiol.12112316.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArea Under CurveCarcinoma, HepatocellularChemoembolization, TherapeuticCone-Beam Computed TomographyDoxorubicinFemaleHumansLeast-Squares AnalysisLiver NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedPredictive Value of TestsProspective StudiesRadiation DosageROC CurveSwineTreatment OutcomeConceptsDual-phase cone-beam CTTranscatheter arterial chemoembolizationPartial tumor responseDrug-eluting beadsTumor responseTumor enhancementCone-beam CT scansHepatocellular carcinomaLogistic regression modelsCone-beam CTVenous phaseCT scanMR findingsMultivariate logistic regression modelMR imagingHCC tumor responseRadiation doseDoxorubicin-eluting beadsMagnetic resonance imagingInstitutional review boardArterial chemoembolizationLiver (EASL) guidelinesRegression modelsProspective studyHCC lesions