1998
Nitric oxide increases the activity of the apical 70-pS K+ channel in TAL of rat kidney
Lu M, Wang X, Wang W. Nitric oxide increases the activity of the apical 70-pS K+ channel in TAL of rat kidney. American Journal Of Physiology 1998, 274: f946-f950. PMID: 9612333, DOI: 10.1152/ajprenal.1998.274.5.f946.Peer-Reviewed Original ResearchConceptsThick ascending limbNitric oxide synthaseNitric oxideRat kidneyL-NAMEL-NAME-induced inhibitionL-arginine methyl esterChannel activityMedullary thick ascending limbEffect of NOEffect of SNAPMM L-argininePatch-clamp techniqueCGMP-dependent pathwayD-NAMECell-attached patchesAngiotensin IIMicroM SNAPNOS activityOxide synthaseL-arginineAscending limbHenle's loopNO donorCGMP concentration
1997
Nitric oxide-induced hyperpolarization stimulates low-conductance Na+ channel of rat CCD
Lu M, Giebisch G, Wang W. Nitric oxide-induced hyperpolarization stimulates low-conductance Na+ channel of rat CCD. American Journal Of Physiology 1997, 272: f498-f504. PMID: 9140051, DOI: 10.1152/ajprenal.1997.272.4.f498.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCyclic GMPElectric ConductivityKidney CortexKidney Tubules, CollectingKineticsMembrane PotentialsModels, BiologicalNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthasePatch-Clamp TechniquesPenicillamineRatsRats, Sprague-DawleyS-Nitroso-N-AcetylpenicillamineSodium ChannelsTime FactorsConceptsL-NAMESodium nitroprussideNitric oxideNitro-L-arginine methyl esterL-NAME-induced decreaseAction of NOL-NAME resultsS-nitroso-N-acetyl penicillamineEffect of NOEffect of SNAPWhole-cell recordingsMicroM sodium nitroprussidePatch-clamp techniqueExogenous NO donorD-NAMENO synthaseMicroM amilorideRat CCDCell recordingsNO donorControl valuesStimulatory effectIndirect actionDependent pathwayHyperpolarization
1996
Effect of angiotensin II on the apical K+ channel in the thick ascending limb of the rat kidney.
Lu M, Zhu Y, Balazy M, Reddy K, Falck J, Wang W. Effect of angiotensin II on the apical K+ channel in the thick ascending limb of the rat kidney. The Journal Of General Physiology 1996, 108: 537-547. PMID: 8972391, PMCID: PMC2229337, DOI: 10.1085/jgp.108.6.537.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAnimalsCell MembraneCytochrome P-450 Enzyme InhibitorsDose-Response Relationship, DrugEnzyme InhibitorsFatty Acids, UnsaturatedHydroxyeicosatetraenoic AcidsIn Vitro TechniquesLoop of HenleNaphthalenesNG-Nitroarginine Methyl EsterPatch-Clamp TechniquesPenicillaminePotassium Channel BlockersPotassium ChannelsRatsRats, Sprague-DawleyS-Nitroso-N-AcetylpenicillamineSodiumConceptsEffect of AIIThick ascending limbAngiotensin IIControl valuesInhibitory effectChannel activityAscending limbRat kidneyL-arginine methyl esterArachidonic acidStimulatory effectExogenous nitric oxide donorNM angiotensin IIMicroM NG-nitroNitric oxide synthaseMajor AA metaboliteNitric oxide donorMicroM calphostin CPatch-clamp techniqueP450-dependent pathwayL-NAMENG-nitroCell-attached patchesOxide synthaseP450 metabolitesNitric oxide regulates the low-conductance K+ channel in basolateral membrane of cortical collecting duct
Lu M, Wang W. Nitric oxide regulates the low-conductance K+ channel in basolateral membrane of cortical collecting duct. American Journal Of Physiology 1996, 270: c1336-c1342. PMID: 8967433, DOI: 10.1152/ajpcell.1996.270.5.c1336.Peer-Reviewed Original ResearchConceptsNitric oxide synthaseCGMP-dependent pathwayL-NAMEL-NIOChannel activityL-arginine methyl esterExogenous nitric oxide donorOutward slope conductanceSlope conductanceNitric oxide donorPatch-clamp techniqueCell-attached patchesInward slope conductanceOxide synthaseBasolateral membraneSodium nitroprussideOxide donorRat kidneyNitric oxideIntermediate conductanceInhibitory effectEffect of NOTetraethylammonium chlorideMicroM NCyclic monophosphate