High-Grade B-Cell Lymphoma, Not Otherwise Specified (HGBL, NOS): Characteristics, Treatment, and Outcomes from 17 Academic US Centers
Zayac A, Landsburg D, Hughes M, Ayers E, Girton M, Hu M, Beckman A, Li S, Medeiros L, Kurt H, Sandoval-Sus J, Ansari-Lari M, Kothari S, Kress A, Xu M, Torka P, Sundaram S, Smith S, Naresh K, Karimi Y, Epperla N, Bond D, Evens A, Pandya K, Naik S, Kamdar M, Haverkos B, Karmali R, Oh T, Vose J, Nutsch H, Rubinstein P, Chaudhry A, Olszewski A. High-Grade B-Cell Lymphoma, Not Otherwise Specified (HGBL, NOS): Characteristics, Treatment, and Outcomes from 17 Academic US Centers. Blood 2021, 138: 455. DOI: 10.1182/blood-2021-144308.Peer-Reviewed Original ResearchInternational Prognostic IndexDA-EPOCHOverall survivalComplete responseB-cell lymphomaWorld Health OrganizationSpeakers bureauADC therapeuticsLactate dehydrogenaseCommon first-line regimensHigh serum lactate dehydrogenaseAdvisory board membersChimeric antigen receptor T cellsCentral nervous system involvementAntigen receptor T cellsGrade B-cell lymphomaAdvisory CommitteeAggressive B-cell lymphomasMYC extra copiesPoor performance statusOutcomes of patientsDe novo tumorsFirst-line regimensNervous system involvementGerminal center B-cell phenotypeThe Atlas of Blood Cancer Genomes (ABCG) Project: A Comprehensive Molecular Characterization of Leukemias and Lymphomas
Love C, Pillai R, Ondrejka S, Bhagat G, Chadburn A, McKinney M, Koff J, Soliman D, Czader M, Louissaint A, Li S, Ong C, Behdad A, Evens A, Natkunam Y, Norgaard P, Leppa S, Tse E, Chapman J, Amador C, Fedoriw Y, Bogusz A, Evans A, Goswami R, Juskevicius R, Xu M, Naresh K, Xiong B, Snowden A, Thurman A, Smith E, Dave T, Kositsky R, Thakkar D, Russell V, Roth C, Dave S. The Atlas of Blood Cancer Genomes (ABCG) Project: A Comprehensive Molecular Characterization of Leukemias and Lymphomas. Blood 2021, 138: 2213. DOI: 10.1182/blood-2021-151346.Peer-Reviewed Original ResearchB-cell lymphomaBlood cancersCell lymphomaSpeakers bureauSystematic genomic approachTherapeutic possibilitiesPrimary mediastinal B-cell lymphomaGenomic approachesLarge B-cell lymphomaCentralized pathology reviewMediastinal B-cell lymphomaCancer Genome ProjectTherapeutic developmentMature B-cell lymphomasDetailed clinical informationClinical data reviewPlasma cell myelomaMolecular featuresWhole-exome sequencingRNA sequencingGenome ProjectMETHODS/RESULTSFoundation MedicinePathologic factorsPathology review