2023
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Young J, Park H, Kim M, Par-Young J, Bartlett H, Kim H, Unlu S, Osmani L, Shin M, Bucala R, van Dyck C, Allore H, Mecca A, You S, Kang I. Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease. Immunity & Ageing 2023, 20: 71. PMID: 38042785, PMCID: PMC10693128, DOI: 10.1186/s12979-023-00396-y.Peer-Reviewed Original ResearchPeripheral bloodT cellsAlzheimer's diseaseEM CD8Memory CD8Gene signatureAge-related immune changesIL-7 receptor alphaEffector memory CD8Strong risk factorT cell expansionAD genesAge-associated expansionImmune changesRisk factorsCD8Dementia patientsIL-7RNeuropsychological testingReceptor alphaNeurocognitive functionRT-qPCR resultsDisease severityPatientsNormal persons
2012
Altered Th17 and Th1 cells responses in patients with primary Sjogren syndrome (59.10)
Kang G, Kim S, Bunin V, Shin M, Lee N, Parke A, Kang I. Altered Th17 and Th1 cells responses in patients with primary Sjogren syndrome (59.10). The Journal Of Immunology 2012, 188: 59.10-59.10. DOI: 10.4049/jimmunol.188.supp.59.10.Peer-Reviewed Original ResearchPrimary Sjogren's syndromeHealthy subjectsIL-7IL-17IL-23Sjogren's syndromeIL-10IL-12Peripheral bloodIL-1βIL-6Th1 cellsTh1-polarizing cytokine IL-12Anti-inflammatory cytokine IL-10Frequencies of Th17Frequency of CD4Cytokine IL-10IL-10 productionSystemic autoimmune diseaseCytokines IL-12IL-12 productionInnate immune cellsMajor proinflammatory cytokineSupernatants of lipopolysaccharideDry mouth