2023
NLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury
Kim H, Kim M, Kim E, Leem J, Baek S, Lee Y, Kim K, Kang M, Song T, Sohn M. NLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury. Scientific Reports 2023, 13: 3441. PMID: 36859435, PMCID: PMC9975446, DOI: 10.1038/s41598-023-28206-x.Peer-Reviewed Original ResearchConceptsHyperoxic acute lung injuryAcute lung injuryLung injuryWT miceAcute respiratory failurePro-inflammatory cytokinesCell deathRespiratory failureAcute injuryInflammatory cellsReduced mortalityRole of NLRX1Murine modelNLRX1 expressionPro-apoptotic signalingCell cytotoxicityHyperoxiaInjuryMiceProtein leakageHyperoxic conditionsNLRX1Apoptotic cell deathERK 1/2Reactive oxygen species
2010
Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma
Koh BH, Hwang SS, Kim JY, Lee W, Kang MJ, Lee CG, Park JW, Flavell RA, Lee GR. Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 10614-10619. PMID: 20483988, PMCID: PMC2890814, DOI: 10.1073/pnas.1005383107.Peer-Reviewed Original ResearchConceptsCD4 T cellsAllergic asthmaTh2 cytokine genesCytokine genesKO miceT cellsNaïve CD4 T cellsLung airway inflammationSerum IgE levelsBronchoalveolar lavage fluidRecruitment of eosinophilsWild-type miceAirway hyperresponsivenessOvalbumin challengeAirway inflammationIgE levelsLavage fluidTh2 cytokinesAirway wallMucus productionMouse modelAsthmaMarked reductionCre-loxP recombinationMice