2022
AgRP neurons control structure and function of the medial prefrontal cortex
Stutz B, Waterson MJ, Šestan-Peša M, Dietrich MO, Škarica M, Sestan N, Racz B, Magyar A, Sotonyi P, Liu ZW, Gao XB, Matyas F, Stoiljkovic M, Horvath TL. AgRP neurons control structure and function of the medial prefrontal cortex. Molecular Psychiatry 2022, 27: 3951-3960. PMID: 35906488, PMCID: PMC9891653, DOI: 10.1038/s41380-022-01691-8.Peer-Reviewed Original ResearchMeSH KeywordsAgouti-Related ProteinAnimalsDopaminergic NeuronsHypothalamusMiceNeuropeptide YPrefrontal CortexConceptsMedial prefrontal cortexAgRP neuronsNon-selective dopamine receptor antagonistBrain functionPrefrontal cortexHypothalamic AgRP neuronsMedial thalamic neuronsAdministration of clozapineDopamine receptor antagonistVentral tegmental areaOscillatory network activityHigher-order brain functionsHypothalamic agoutiThalamic neuronsChemogenetic inhibitionDopaminergic neuronsReceptor antagonistTegmental areaNeuronal pathwaysSensorimotor gatingAdult miceModulatory impactAmbulatory behaviorConstitutive impairmentNeurons
2016
Activation of α7 nicotinic acetylcholine receptors facilitates long-term potentiation at the hippocampal-prefrontal cortex synapses in vivo
Stoiljkovic M, Kelley C, Nagy D, Hurst R, Hajós M. Activation of α7 nicotinic acetylcholine receptors facilitates long-term potentiation at the hippocampal-prefrontal cortex synapses in vivo. European Neuropsychopharmacology 2016, 26: 2018-2023. PMID: 27866776, DOI: 10.1016/j.euroneuro.2016.11.003.Peer-Reviewed Original ResearchConceptsHippocampal-medial prefrontal cortex pathwayHippocampal-prefrontal cortex pathwayLong-term potentiationPrefrontal cortex pathwayCognitive processesCortex pathwayCognitive effectsMnemonic functionsCognitive functionMemory formationNeurophysiological effectsΑ7-nAChR activationNAChR activationΑ7 nAChRsHippocampal long-term potentiationSubiculum regionsΑ7 nicotinic acetylcholine receptorNicotinic acetylcholine receptorsMale ratsSaline controlsSynaptic transmissionBrain slicesTetanic stimulationAcetylcholine receptorsSynaptic plasticity