1996
Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro
Escribano J, Alonso G, Coca-Prados M, Fernández J. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Letters 1996, 100: 23-30. PMID: 8620447, DOI: 10.1016/0304-3835(95)04067-6.Peer-Reviewed Original ResearchConceptsExtract of saffronCytotoxic effectsCell growth inhibitionCancer therapeutic agentsHuman tumor cellsHuman cancer cellsPyknotic nucleiInhibitory growth effectTherapeutic agentsTumor cellsCancer cellsEthanolic extractApoptosis inductionCrocinGrowth inhibitionReduced cytoplasmCell growthCellsCrocetinCell shrinkageDosesHeLa cells
1995
Immortalization of cat iris sphincter smooth muscle cells by SV40 virus: Growth, morphological, biochemical and pharmacological characteristics
Ocklind A, Yousufzai S, Ghosh S, Coca-Prados M, St Jernschantz J, Abdel-Latif A. Immortalization of cat iris sphincter smooth muscle cells by SV40 virus: Growth, morphological, biochemical and pharmacological characteristics. Experimental Eye Research 1995, 61: 535-545. PMID: 8654496, DOI: 10.1016/s0014-4835(05)80047-8.Peer-Reviewed Original ResearchConceptsSignal transduction pathwaysCat iris sphincter smooth muscle cellsSmooth muscle alpha-actinMuscle alpha-actinImmortalized cellsTransduction pathwaysSmooth muscle cellsMuscle cellsAlpha-actinImportant model systemSV40 virusLarge T antigenImmortalized cell culturesMlc proteinNormal muscle cellsTransformation phenotypeSuccessful immortalizationLow-serum mediumCellular DNAContact inhibitionPopulation doublingsSV-CISM-2 cellsT antigenViral transformationArachidonic acid
1986
Transformation of human ciliary epithelial cells by simian virus 40: induction of cell proliferation and retention of beta 2-adrenergic receptors.
Coca-Prados M, Wax M. Transformation of human ciliary epithelial cells by simian virus 40: induction of cell proliferation and retention of beta 2-adrenergic receptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 8754-8758. PMID: 3022303, PMCID: PMC387010, DOI: 10.1073/pnas.83.22.8754.Peer-Reviewed Original ResearchConceptsSimian virus 40Ciliary epithelial cellsSouthern blot analysisLarge tumor antigenHuman ciliary epithelial cellsEpithelial cellsFunctional conservationProtein phosphorylationDirect bindingCell DNAParent cellsBlot analysisCell proliferationCellular cAMP productionReceptor-mediated processEpithelial cell DNAViral DNAImmunoprecipitationDNACAMP productionSelective drugsCell clonesMembrane preparationsCellsReceptors