2017
Quantitative distribution of Zn, Fe and Cu in the human lens and study of the Zn–metallothionein redox system in cultured lens epithelial cells by elemental MS
González-Iglesias H, Petrash C, Rodríguez-Menéndez S, García M, Álvarez L, Fernández-Vega Cueto L, Fernández B, Pereiro R, Sanz-Medel A, Coca-Prados M. Quantitative distribution of Zn, Fe and Cu in the human lens and study of the Zn–metallothionein redox system in cultured lens epithelial cells by elemental MS. Journal Of Analytical Atomic Spectrometry 2017, 32: 1746-1756. DOI: 10.1039/c6ja00431h.Peer-Reviewed Original ResearchLens epithelial cellsMolecular mass proteinsMass proteinsCultured human lens epithelial cellsHigh molecular mass proteinsEpithelial cellsCultured lens epithelial cellsHuman lens epithelial cellsHuman lensOxidative cellular damageLocalization of ZnEndogenous stressorsImportant enzymeMT proteinCellular distributionLens epithelial cell layerProteinRedox systemEpithelial cell layerElemental mass spectrometryCellular damageMetallothioneinOxidative stressHuman lensesCells
2016
The zinc‐metallothionein redox system in human retina and RPE
Alvarez L, García M, Rodríguez S, Fernández B, Pereiro R, Sanz‐Medel A, Coca‐Prados M, González‐Iglesias H. The zinc‐metallothionein redox system in human retina and RPE. Acta Ophthalmologica 2016, 94 DOI: 10.1111/j.1755-3768.2016.0560.Peer-Reviewed Original ResearchHuman RPE cellsInflammatory cytokinesNeuroprotective functionOxidative stress processesEye sectionsNeural retinaHuman donorsRPE cellsRetinaHuman retinaHuman eyeRPEMT proteinExogenous zincCellular zinc homeostasisCellular modelZinc homeostasisMain regulatorStoichiometric transitionsEyesBinding profileProtein binding profileProtein synthesisLesser levelsMetallothionein