2017
p120-Catenin Downregulation and PIK3CA Mutations Cooperate to Induce Invasion through MMP1 in HNSCC
Kidacki M, Lehman HL, Green MV, Warrick JI, Stairs DB. p120-Catenin Downregulation and PIK3CA Mutations Cooperate to Induce Invasion through MMP1 in HNSCC. Molecular Cancer Research 2017, 15: 1398-1409. PMID: 28637905, DOI: 10.1158/1541-7786.mcr-17-0108.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Squamous CellCateninsCell Line, TumorCell MovementClass I Phosphatidylinositol 3-KinasesDelta CateninDown-RegulationGene Expression Regulation, NeoplasticHead and Neck NeoplasmsHumansMatrix Metalloproteinase 1MutationNeoplasm InvasivenessSquamous Cell Carcinoma of Head and NeckConceptsPI3K pathway mutationsNeck squamous cell carcinomaPathway mutationsInhibition of MMP1Squamous cell carcinomaSubset of HNSCCsPotential novel targetAdvanced diseaseCancer Genome AtlasCell carcinomaPIK3CA mutationsHNSCC invasionOral keratinocytesPatient specimensCancer ResHNSCCNovel targetMetastasisMMP1Genome AtlasPotential targetDownregulationIdentification of mechanismsAggressive behaviorInvasion
2012
Paracrine interactions between primary human macrophages and human fibroblasts enhance murine mammary gland humanization in vivo
Fleming JM, Miller TC, Kidacki M, Ginsburg E, Stuelten CH, Stewart DA, Troester MA, Vonderhaar BK. Paracrine interactions between primary human macrophages and human fibroblasts enhance murine mammary gland humanization in vivo. Breast Cancer Research 2012, 14: r97. PMID: 22731827, PMCID: PMC3446360, DOI: 10.1186/bcr3215.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MovementCell ProliferationChemokinesCytokinesEstrogensFemaleFibroblastsHumansMacrophagesMammary Glands, AnimalMammary Neoplasms, ExperimentalMatrix Metalloproteinase 9MiceMice, Inbred NODMice, SCIDParacrine CommunicationProliferating Cell Nuclear AntigenSignal TransductionStromal CellsTumor Necrosis Factor-alphaConceptsPrimary human macrophagesHuman macrophagesEstrogen stimulationVivo modelParacrine interactionsCell nuclear antigen-positive cellsMammary glandAntigen-positive cellsVivo resultsStromal-derived signalsEpithelial cell proliferationCell interactionsNormal gland developmentTreatment of macrophagesMurine mammary glandMouse mammary glandVivo model systemsWestern analysisBreast functionMMP9 expressionImmunohistochemical analysisPositive cellsImmunohistological analysisMammary microenvironmentTumor growth