2001
Pharmacokinetics and Pharmacodynamics of Recombinant FGF‐2 in a Phase I Trial in Coronary Artery Disease
Bush M, Samara E, Whitehouse MJ, Yoshizawa C, Novicki D, Pike M, Laham R, Simons M, Chronos N. Pharmacokinetics and Pharmacodynamics of Recombinant FGF‐2 in a Phase I Trial in Coronary Artery Disease. The Journal Of Clinical Pharmacology 2001, 41: 378-385. PMID: 11304894, DOI: 10.1177/00912700122010230.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overArea Under CurveCoronary DiseaseEnzyme-Linked Immunosorbent AssayFemaleFibroblast Growth Factor 2Follow-Up StudiesHemodynamicsHeparinHumansInfusions, IntravenousMaleMaximum Tolerated DoseMetabolic Clearance RateMiddle AgedRecombinant ProteinsRegression AnalysisTime FactorsConceptsRecombinant FGF-2Coronary artery diseasePhase I trialFibroblast growth factor-2Artery diseaseI trialSystemic exposureSevere coronary artery diseaseTerminal elimination t1/2Peak plasma concentrationConcentration-time curveMultiple animal modelsDose-response relationshipAcute hemodynamicsGrowth factor 2Chronic ischemiaElimination t1/2Intravenous infusionSingle doseLinear pharmacokineticsDistribution t1/2Plasma concentrationsIntravenous administrationBiphasic eliminationSlow clearanceEfficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia
Sato K, Wu T, Laham R, Johnson R, Douglas P, Li J, Sellke F, Bunting S, Simons M, Post M. Efficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia. Journal Of The American College Of Cardiology 2001, 37: 616-623. PMID: 11216988, DOI: 10.1016/s0735-1097(00)01144-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCoronary CirculationDose-Response Relationship, DrugEndothelial Growth FactorsEndothelium, VascularInfusions, Intra-ArterialInfusions, IntravenousLymphokinesMaleMicrocirculationMyocardial ContractionMyocardial IschemiaSwineVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsChronic myocardial ischemiaMyocardial ischemiaL-NAMEIntracoronary groupBlood flowNitro-L-arginine methyl ester hydrochlorideNitric oxide synthase inhibitionEndothelial growth factor treatmentLeft circumflex coronary arteryDose-limiting hypotensionOxide synthase inhibitionCircumflex coronary arteryVascular endothelial growth factor treatmentMyocardial blood flowRegional myocardial functionGrowth factor treatmentVEGF-induced angiogenesisIntravenous groupConcomitant administrationMicrovascular functionIntracoronary infusionCollateral indexDifferent regimensCoronary arteryIntravenous infusion
2000
Efficacy of intracoronary versus intravenous FGF-2 in a pig model of chronic myocardial ischemia
Sato K, Laham R, Pearlman J, Novicki D, Sellke F, Simons M, Post M. Efficacy of intracoronary versus intravenous FGF-2 in a pig model of chronic myocardial ischemia. The Annals Of Thoracic Surgery 2000, 70: 2113-2118. PMID: 11156130, DOI: 10.1016/s0003-4975(00)02018-x.Peer-Reviewed Original ResearchConceptsChronic myocardial ischemiaRegional blood flowIschemic myocardiumFGF-2Myocardial ischemiaBlood flowPig modelML/min/Perfusion magnetic resonance imagingSingle intravenous infusionGrowth factor administrationRegional wall motionMagnetic resonance imagingAngiographic collateralsIntracoronary treatmentEjection fractionIntracoronary infusionIntravenous infusionIschemic areaFactor administrationMyocardial functionColored microspheresMyocardial perfusionResonance imagingTherapeutic angiogenesis