2025
Bridging Care Gaps for Older Women Undergoing Percutaneous Coronary Intervention
Kalra K, Sampath R, Cigarroa N, Sutton N, Damluji A, Nanna M. Bridging Care Gaps for Older Women Undergoing Percutaneous Coronary Intervention. Interventional Cardiology Clinics 2025, 14: 69-79. PMID: 39537289, DOI: 10.1016/j.iccl.2024.08.006.Peer-Reviewed Original Research
2024
Invasive Versus Conservative Strategy in Older Adults ≥75 Years of Age With Non-ST-segment-Elevation Acute Coronary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Rout A, Moumneh M, Kalra K, Singh S, Garg A, Kunadian V, Biscaglia S, Alkhouli M, Rymer J, Batchelor W, Nanna M, Damluji A. Invasive Versus Conservative Strategy in Older Adults ≥75 Years of Age With Non-ST-segment-Elevation Acute Coronary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal Of The American Heart Association 2024, 13: e036151. PMID: 39494560, DOI: 10.1161/jaha.124.036151.Peer-Reviewed Original ResearchConceptsNon-ST segment elevation acute coronary syndromeAcute coronary syndromeComposite of deathBurden of geriatric conditionsRandomized controlled trialsCoronary syndromeMyocardial infarctionYears of ageInvasive strategyOlder adultsControlled trialsGeriatric conditionsOlder patientsCardiovascular deathOdds ratioMeta-analysis of randomized controlled trialsNon-ST segment elevationSecondary end pointsMeta-analysisFixed effects meta-analysisAll-cause deathEffects meta-analysisYounger patientsFollow-upDecreased riskChronological vs Biological Age in Interventional Cardiology A Comprehensive Approach to Care for Older Adults: JACC Family Series
Damluji A, Nanna M, Rymer J, Kochar A, Lowenstern A, Baron S, Narins C, Alkhouli M. Chronological vs Biological Age in Interventional Cardiology A Comprehensive Approach to Care for Older Adults: JACC Family Series. JACC Cardiovascular Interventions 2024, 17: 961-978. PMID: 38597844, PMCID: PMC11097960, DOI: 10.1016/j.jcin.2024.01.284.Peer-Reviewed Original ResearchConceptsCardiovascular careImprove health outcomesOlder adult populationPatient-centered outcomesBiological ageAge-associated riskAging global populationAge-related riskFamily seriesComplex careHealth outcomesJACC State-of-the-Art ReviewOlder AdultsChronic illnessInfluence eligibilityProcedural adverse eventsStructural heart diseaseClinical focusCareOlder individualsInvasive careAdult populationInterventionCardiovascular diseaseOlder patients
2022
Primary prevention statin therapy in older adults
Nanna M, Abdullah A, Mortensen M, Navar A. Primary prevention statin therapy in older adults. Current Opinion In Cardiology 2022, 38: 11-20. PMID: 36598445, PMCID: PMC9830552, DOI: 10.1097/hco.0000000000001003.Peer-Reviewed Original ResearchConceptsAge 75Older adult populationStatin treatmentRandomized trialsAdult populationPrimary prevention statin therapyOlder adultsAverage lifespan increasesRecent guideline recommendationsACC/AHAOngoing randomized trialsPrevention of morbidityPaucity of evidenceStatin therapyStatin useUSPSTF recommendationsOlder patientsGuideline recommendationsOngoing trialsTreatment recommendationsCardiovascular diseaseTreatment benefitTreatment decisionsGuidelines conflictTrials
2020
Representation of Older Adults in Cardiovascular Disease Trials Since the Inclusion Across the Lifespan Policy
Nanna MG, Chen ST, Nelson AJ, Navar AM, Peterson ED. Representation of Older Adults in Cardiovascular Disease Trials Since the Inclusion Across the Lifespan Policy. JAMA Internal Medicine 2020, 180: 1531-1533. PMID: 32897289, PMCID: PMC7489390, DOI: 10.1001/jamainternmed.2020.2750.Peer-Reviewed Original ResearchPresentation, Treatment, and Outcomes of the Oldest-Old Patients with Acute Myocardial Infarction: The SILVER-AMI Study
Gupta A, Tsang S, Hajduk A, Krumholz HM, Nanna MG, Green P, Dodson JA, Chaudhry SI. Presentation, Treatment, and Outcomes of the Oldest-Old Patients with Acute Myocardial Infarction: The SILVER-AMI Study. The American Journal Of Medicine 2020, 134: 95-103. PMID: 32805225, PMCID: PMC7752813, DOI: 10.1016/j.amjmed.2020.07.020.Peer-Reviewed Original ResearchConceptsOldest-old patientsMyocardial infarctionFunctional impairmentOlder patientsMobility impairmentsCox proportional hazards regressionMiddle-old patientsProportional hazards regressionAcute myocardial infarctionCase fatality rateAcute myocardial infarction hospitalizationsSILVER-AMI StudyYears of ageMyocardial infarction hospitalizationsChest painCoronary revascularizationAtypical presentationHazards regressionClinical variablesRisk factorsAdvanced agePrimary symptomsPatientsFatality rateHealth statusPerformance of Guideline Recommendations for Prevention of Myocardial Infarction in Young Adults
Zeitouni M, Nanna MG, Sun JL, Chiswell K, Peterson ED, Navar AM. Performance of Guideline Recommendations for Prevention of Myocardial Infarction in Young Adults. Journal Of The American College Of Cardiology 2020, 76: 653-664. PMID: 32762899, PMCID: PMC7444655, DOI: 10.1016/j.jacc.2020.06.030.Peer-Reviewed Original ResearchConceptsLipid-lowering therapyYears of agePremature myocardial infarctionIntensive lipid-lowering therapyHigh-risk criteriaMyocardial infarctionYoung adultsYounger patientsHigh low-density lipoprotein cholesterolAHA/ACC guidelinesMajor adverse cardiovascular eventsLow-density lipoprotein cholesterolDuke University Medical CenterACC/AHAAdverse cardiovascular eventsRecurrent myocardial infarctionMost young patientsReductase inhibitor therapyFirst myocardial infarctionAmerican Heart AssociationUniversity Medical CenterOlder age groupsCause deathCholesterol guidelinesStatin candidatesAge-Related Differences in the Noninvasive Evaluation for Possible Coronary Artery Disease
Lowenstern A, Alexander KP, Hill CL, Alhanti B, Pellikka PA, Nanna MG, Mehta RH, Cooper LS, Bullock-Palmer RP, Hoffmann U, Douglas PS. Age-Related Differences in the Noninvasive Evaluation for Possible Coronary Artery Disease. JAMA Cardiology 2020, 5: 193-201. PMID: 31738382, PMCID: PMC6865842, DOI: 10.1001/jamacardio.2019.4973.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseOlder patientsMyocardial infarctionCV deathNoninvasive testsArtery diseaseNoninvasive evaluationElevated coronary artery calcium scoresDeath/myocardial infarctionPositive noninvasive test resultsPossible coronary artery diseaseProspective Multicenter Imaging StudyCoronary artery calcium scoreNonwhite race/ethnicityComparative effectiveness designArtery calcium scoreCoronary artery calciumMinority of patientsCause of morbidityNoninvasive test resultsFunctional test resultsAge-specific approachesBest noninvasive testPositive test resultsOlder age groups
2019
Age, knowledge, preferences, and risk tolerance for invasive cardiac care
Nanna MG, Peterson ED, Wu A, Harding T, Galanos AN, Wruck L, Alexander KP. Age, knowledge, preferences, and risk tolerance for invasive cardiac care. American Heart Journal 2019, 219: 99-108. PMID: 31733450, PMCID: PMC6944066, DOI: 10.1016/j.ahj.2019.09.008.Peer-Reviewed Original ResearchConceptsInvasive cardiac careAcute coronary syndromeInvasive cardiovascular proceduresCardiac careCardiovascular proceduresSingle academic medical centerCoronary artery bypassProspective cohort studyPercutaneous coronary interventionGroup of patientsConfidence intervalsSubstantial inter-individual variabilityAcademic medical centerArtery bypassCABG surgeryCoronary syndromeBaseline characteristicsCohort studyCoronary interventionYounger patientsCardiac catheterizationInvasive careInter-individual variabilityCare teamCardiovascular careSex-Based Differences in Presentation, Treatment, and Complications Among Older Adults Hospitalized for Acute Myocardial Infarction
Nanna MG, Hajduk AM, Krumholz HM, Murphy TE, Dreyer RP, Alexander KP, Geda M, Tsang S, Welty FK, Safdar B, Lakshminarayan DK, Chaudhry SI, Dodson JA. Sex-Based Differences in Presentation, Treatment, and Complications Among Older Adults Hospitalized for Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005691. PMID: 31607145, PMCID: PMC6913190, DOI: 10.1161/circoutcomes.119.005691.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overComorbidityDisability EvaluationFemaleHealth Status DisparitiesHealthcare DisparitiesHumansLife StyleMaleMyocardial RevascularizationNon-ST Elevated Myocardial InfarctionPatient AdmissionPrevalenceProspective StudiesRisk AssessmentRisk FactorsSex FactorsSocial Determinants of HealthST Elevation Myocardial InfarctionTime FactorsTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionSex-based differencesPercutaneous coronary interventionFunctional impairmentOlder adultsHospital complicationsCoronary interventionOlder patientsCoronary diseaseMyocardial infarctionAge-related functional impairmentsAge-associated functional impairmentsLower ratesPrior coronary diseaseObstructive coronary diseaseProspective observational studyNSTEMI subgroupSTEMI subgroupUnderwent revascularizationAcute myocardialChest painClinical presentationAMI subgroupRisk factorsHigh prevalenceThirty-Day Readmission Risk Model for Older Adults Hospitalized With Acute Myocardial Infarction
Dodson JA, Hajduk AM, Murphy TE, Geda M, Krumholz HM, Tsang S, Nanna MG, Tinetti ME, Goldstein D, Forman DE, Alexander KP, Gill TM, Chaudhry SI. Thirty-Day Readmission Risk Model for Older Adults Hospitalized With Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005320. PMID: 31010300, PMCID: PMC6481309, DOI: 10.1161/circoutcomes.118.005320.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overFemaleGeriatric AssessmentHealth Status IndicatorsHumansMaleMyocardial InfarctionPatient AdmissionPatient ReadmissionPredictive Value of TestsProspective StudiesReproducibility of ResultsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionReadmission risk modelFinal risk modelFunctional mobilityFunctional impairmentMyocardial infarctionOlder adultsFirst diastolic blood pressureChronic obstructive pulmonary diseaseAge-related functional impairmentsP2Y12 inhibitor useAcute kidney injuryDaily living (ADL) disabilityPatient-level factorsProspective cohort studyDiastolic blood pressureObstructive pulmonary diseasePatients of ageGeneral health statusStrongest predictorRisk modelMore comorbiditiesCause readmissionKidney injuryCohort study
2018
Statin Use and Adverse Effects Among Adults >75 Years of Age: Insights From the Patient and Provider Assessment of Lipid Management (PALM) Registry
Nanna MG, Navar AM, Wang TY, Mi X, Virani SS, Louie MJ, Lee LV, Goldberg AC, Roger VL, Robinson J, Peterson ED. Statin Use and Adverse Effects Among Adults >75 Years of Age: Insights From the Patient and Provider Assessment of Lipid Management (PALM) Registry. Journal Of The American Heart Association 2018, 7: e008546. PMID: 29739801, PMCID: PMC6015311, DOI: 10.1161/jaha.118.008546.Peer-Reviewed Original ResearchConceptsLipid Management (PALM) registryHigh-dose statinsHigh-intensity statinsStatin useOlder patientsSecondary preventionManagement RegistryPrimary preventionProvider assessmentCardiology/American Heart Association guidelinesAmerican Heart Association guidelinesMultivariable logistic regression modelRoutine community practiceHeart Association guidelinesCurrent statin usersCurrent statin useYears of ageLogistic regression modelsStatin usersYounger patientsPatient surveyAssociation guidelinesAmerican CollegeStatinsPatients