2004
Genetic Analysis of RGS Protein Function in Caenorhabditis elegans
Chase DL, Koelle MR. Genetic Analysis of RGS Protein Function in Caenorhabditis elegans. Methods In Enzymology 2004, 389: 305-320. PMID: 15313573, DOI: 10.1016/s0076-6879(04)89018-9.Peer-Reviewed Original ResearchConceptsRGS proteinsC. elegansG proteinsRGS protein functionStructure/function studiesG protein geneCaenorhabditis elegansGalpha mutantsClose homologProtein functionGalpha proteinsElegansGenetic analysisDetailed protocolTransgenic expressionProteinMost mammaliansMutantsFunction studiesOrthologsCaenorhabditisHomologMammalianGenesOrganisms
1996
EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins
Koelle M, Horvitz H. EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins. Cell 1996, 84: 115-125. PMID: 8548815, DOI: 10.1016/s0092-8674(00)80998-8.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAmino Acid SequenceAnimalsBase SequenceCaenorhabditis elegansCaenorhabditis elegans ProteinsConserved SequenceFungal ProteinsGene DosageGenes, HelminthGTP-Binding ProteinsMammalsMolecular Sequence DataMusclesMutationNervous SystemNervous System Physiological PhenomenaOvumProteinsRatsRGS ProteinsSerotoninSignal TransductionYeastsConceptsEGL-10G proteinsNematode C. elegansG protein signalingMammalian genesGOA-1Mammalian proteinsC. elegansConserved domainProtein signalingNegative regulatorNeurotransmitter signalingProteinSignalingDose-dependent mannerPathwaySst2pElegansYeastGenesNervous systemDose-dependent fashionRegulatorCertain periodic behaviorsActivity