2020
Cellular Expression and Functional Roles of All 26 Neurotransmitter GPCRs in the C. elegans Egg-Laying Circuit
Fernandez RW, Wei K, Wang EY, Mikalauskaite D, Olson A, Pepper J, Christie N, Kim S, Weissenborn S, Sarov M, Koelle MR. Cellular Expression and Functional Roles of All 26 Neurotransmitter GPCRs in the C. elegans Egg-Laying Circuit. Journal Of Neuroscience 2020, 40: 7475-7488. PMID: 32847964, PMCID: PMC7511189, DOI: 10.1523/jneurosci.1357-20.2020.Peer-Reviewed Original ResearchConceptsEgg-laying circuitNeurotransmitter GPCREgg-laying defectsModel organismsNeural circuitsExtrasynaptic signalsStandard laboratory conditionsSuch signalingGPCR expressionCell typesFunctional roleGPCRsNeurotransmitter signalsCellular expressionActivity of neuronsModel systemEpithelial cellsReceptor functionOrganismsNeurotransmitter receptorsLaboratory conditionsDistinct receptorsReceptor knockoutParkinson's diseaseCells
2012
The G protein regulator AGS-3 allows C. elegans to alter behaviors in response to food deprivation
Hofler C, Koelle MR. The G protein regulator AGS-3 allows C. elegans to alter behaviors in response to food deprivation. Worm 2012, 1: 56-60. PMID: 24058824, PMCID: PMC3670173, DOI: 10.4161/worm.19042.Peer-Reviewed Original ResearchC. elegansAGS-3Genetic model organismRIC-8Model organismsMolecular mechanismsElegansG proteinsBehavioral responsesFood deprivationO familyGαoProteinNervous system functionBiochemical changesNeural responsesBrain actRecent studiesFood-seeking behaviorHuman obesityFood restrictionOrganismsSpeciesDeprivationObesity