2020
Cellular Expression and Functional Roles of All 26 Neurotransmitter GPCRs in the C. elegans Egg-Laying Circuit
Fernandez RW, Wei K, Wang EY, Mikalauskaite D, Olson A, Pepper J, Christie N, Kim S, Weissenborn S, Sarov M, Koelle MR. Cellular Expression and Functional Roles of All 26 Neurotransmitter GPCRs in the C. elegans Egg-Laying Circuit. Journal Of Neuroscience 2020, 40: 7475-7488. PMID: 32847964, PMCID: PMC7511189, DOI: 10.1523/jneurosci.1357-20.2020.Peer-Reviewed Original ResearchConceptsEgg-laying circuitNeurotransmitter GPCREgg-laying defectsModel organismsNeural circuitsExtrasynaptic signalsStandard laboratory conditionsSuch signalingGPCR expressionCell typesFunctional roleGPCRsNeurotransmitter signalsCellular expressionActivity of neuronsModel systemEpithelial cellsReceptor functionOrganismsNeurotransmitter receptorsLaboratory conditionsDistinct receptorsReceptor knockoutParkinson's diseaseCells
2012
Receptors and Other Signaling Proteins Required for Serotonin Control of Locomotion in Caenorhabditis elegans
Gürel G, Gustafson MA, Pepper JS, Horvitz HR, Koelle MR. Receptors and Other Signaling Proteins Required for Serotonin Control of Locomotion in Caenorhabditis elegans. Genetics 2012, 192: 1359-1371. PMID: 23023001, PMCID: PMC3512144, DOI: 10.1534/genetics.112.142125.Peer-Reviewed Original ResearchConceptsCaenorhabditis elegansLarge-scale genetic screensSer-4Direct postsynaptic targetsGenetic screenC. elegansSignaling proteinsGenetic systemNon-overlapping setsAdditional proteinsExtrasynaptic signalsMolecular mechanismsElegansSerotonin responseGenesRelease sitesMod 1Multiple receptorsProteinSerotonin controlSerotonergic neuronsPostsynaptic targetsSerotonin functionReceptorsSerotonin receptors