2022
Transcriptional profiling of macrophages in situ in metastatic melanoma reveals localization-dependent phenotypes and function
Martinek J, Lin J, Kim KI, Wang VG, Wu TC, Chiorazzi M, Boruchov H, Gulati A, Seeniraj S, Sun L, Marches F, Robson P, Rongvaux A, Flavell RA, George J, Chuang JH, Banchereau J, Palucka K. Transcriptional profiling of macrophages in situ in metastatic melanoma reveals localization-dependent phenotypes and function. Cell Reports Medicine 2022, 3: 100621. PMID: 35584631, PMCID: PMC9133468, DOI: 10.1016/j.xcrm.2022.100621.Peer-Reviewed Original ResearchConceptsMonocytes/macrophagesDendritic cellsMetastatic melanomaMelanoma cellsMetastatic cutaneous melanomaRegulation of toleranceSpecific transcriptional signatureTranscriptional profilingGene setsLaser capture microdissectionCell-based therapiesTranscriptional signatureCutaneous melanomaDC functionPatient outcomesMetastatic cancerTumor nestsTCGA cohortImmune functionCandidate biomarkersCD14Stromal macrophagesTumor siteTherapeutic opportunitiesAntigen capture
2004
Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune Cells
Dave SS, Wright G, Tan B, Rosenwald A, Gascoyne RD, Chan W, Fisher RI, Braziel RM, Rimsza LM, Grogan TM, Miller TP, LeBlanc M, Greiner TC, Weisenburger DD, Lynch JC, Vose J, Armitage JO, Smeland EB, Kvaloy S, Holte H, Delabie J, Connors JM, Lansdorp PM, Ouyang Q, Lister TA, Davies AJ, Norton AJ, Muller-Hermelink HK, Ott G, Campo E, Montserrat E, Wilson WH, Jaffe ES, Simon R, Yang L, Powell J, Zhao H, Goldschmidt N, Chiorazzi M, Staudt LM. Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune Cells. New England Journal Of Medicine 2004, 351: 2159-2169. PMID: 15548776, DOI: 10.1056/nejmoa041869.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiopsyDendritic CellsFemaleFollow-Up StudiesGene ExpressionGene Expression ProfilingHumansLymphocytes, Tumor-InfiltratingLymphoma, FollicularMacrophagesMaleMiddle AgedMultivariate AnalysisOligonucleotide Array Sequence AnalysisPrognosisProportional Hazards ModelsSurvival AnalysisConceptsLength of survivalImmune cellsFollicular lymphomaMolecular predictorsTumor-Infiltrating Immune CellsClinical prognostic variablesNonmalignant immune cellsUntreated follicular lymphomaTumor biopsy specimensPrediction of survivalMolecular featuresGene expression signaturesMedian lengthSurvival predictorsBiopsy specimensPrognostic variablesPatientsGene expression profilesFlow cytometryGene expression profilingLymphomaSurvivalDiagnosisIndividual genesExpression patterns