2007
Characterization of Early Stages of Human B Cell Development by Gene Expression Profiling
Hystad ME, Myklebust JH, Bø TH, Sivertsen EA, Rian E, Forfang L, Munthe E, Rosenwald A, Chiorazzi M, Jonassen I, Staudt LM, Smeland EB. Characterization of Early Stages of Human B Cell Development by Gene Expression Profiling. The Journal Of Immunology 2007, 179: 3662-3671. PMID: 17785802, DOI: 10.4049/jimmunol.179.6.3662.Peer-Reviewed Original ResearchConceptsHuman B cell developmentB cell developmentGene expression profilingCell developmentTranscription factorsExpression profilingHemopoietic stem cellsLineage-associated transcription factorsInteresting expression patternsStem cellsMyeloid-associated genesExpression of genesAdult bone marrowFunctional assignmentImmature B cellsKey genesCDNA microarrayGene setsExpression patternsVDJ recombinationUnknown roleB-lymphoid cellsGenesB cellsRNA amplification
2004
Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune Cells
Dave SS, Wright G, Tan B, Rosenwald A, Gascoyne RD, Chan W, Fisher RI, Braziel RM, Rimsza LM, Grogan TM, Miller TP, LeBlanc M, Greiner TC, Weisenburger DD, Lynch JC, Vose J, Armitage JO, Smeland EB, Kvaloy S, Holte H, Delabie J, Connors JM, Lansdorp PM, Ouyang Q, Lister TA, Davies AJ, Norton AJ, Muller-Hermelink HK, Ott G, Campo E, Montserrat E, Wilson WH, Jaffe ES, Simon R, Yang L, Powell J, Zhao H, Goldschmidt N, Chiorazzi M, Staudt LM. Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune Cells. New England Journal Of Medicine 2004, 351: 2159-2169. PMID: 15548776, DOI: 10.1056/nejmoa041869.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiopsyDendritic CellsFemaleFollow-Up StudiesGene ExpressionGene Expression ProfilingHumansLymphocytes, Tumor-InfiltratingLymphoma, FollicularMacrophagesMaleMiddle AgedMultivariate AnalysisOligonucleotide Array Sequence AnalysisPrognosisProportional Hazards ModelsSurvival AnalysisConceptsLength of survivalImmune cellsFollicular lymphomaMolecular predictorsTumor-Infiltrating Immune CellsClinical prognostic variablesNonmalignant immune cellsUntreated follicular lymphomaTumor biopsy specimensPrediction of survivalMolecular featuresGene expression signaturesMedian lengthSurvival predictorsBiopsy specimensPrognostic variablesPatientsGene expression profilesFlow cytometryGene expression profilingLymphomaSurvivalDiagnosisIndividual genesExpression patterns
2003
Molecular Diagnosis of Primary Mediastinal B Cell Lymphoma Identifies a Clinically Favorable Subgroup of Diffuse Large B Cell Lymphoma Related to Hodgkin Lymphoma
Rosenwald A, Wright G, Leroy K, Yu X, Gaulard P, Gascoyne RD, Chan WC, Zhao T, Haioun C, Greiner TC, Weisenburger DD, Lynch JC, Vose J, Armitage JO, Smeland EB, Kvaloy S, Holte H, Delabie J, Campo E, Montserrat E, Lopez-Guillermo A, Ott G, Muller-Hermelink HK, Connors JM, Braziel R, Grogan TM, Fisher RI, Miller TP, LeBlanc M, Chiorazzi M, Zhao H, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Staudt LM. Molecular Diagnosis of Primary Mediastinal B Cell Lymphoma Identifies a Clinically Favorable Subgroup of Diffuse Large B Cell Lymphoma Related to Hodgkin Lymphoma. Journal Of Experimental Medicine 2003, 198: 851-862. PMID: 12975453, PMCID: PMC2194208, DOI: 10.1084/jem.20031074.Peer-Reviewed Original ResearchMeSH KeywordsAdultChromosomes, Human, Pair 19Diagnosis, DifferentialGene Expression ProfilingHodgkin DiseaseHumansLymphoma, B-CellLymphoma, Large B-Cell, DiffuseMediastinal NeoplasmsMiddle AgedMolecular Diagnostic TechniquesOligonucleotide Array Sequence AnalysisSurvival RateTreatment OutcomeTumor Cells, CulturedConceptsGene expressionHodgkin's lymphoma cellsGenomic lociNeighboring genesMolecular diagnosisPMBL patientsPrimary mediastinal B-cell lymphomaLymphoma cellsHodgkin's lymphoma cell linesLymphoma cell linesDiffuse large B-cell lymphomaDevelopment of therapiesGenesT cell activationPrecise molecular diagnosisCell linesB-cell lymphomaMediastinal B-cell lymphomaLarge B-cell lymphomaCell activationCell lymphomaExpressionHodgkin's lymphomaDLBCL patientsCellsThe proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma
Rosenwald A, Wright G, Wiestner A, Chan C, Connors JM, Campo E, Gascoyne RD, Grogan TM, Muller-Hermelink HK, Smeland EB, Chiorazzi M, Giltnane JM, Hurt EM, Zhao H, Averett L, Henrickson S, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Montserrat E, Bosch F, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Fisher RI, Miller TP, LeBlanc M, Ott G, Kvaloy S, Holte H, Delabie J, Staudt LM. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell 2003, 3: 185-197. PMID: 12620412, DOI: 10.1016/s1535-6108(03)00028-x.Peer-Reviewed Original ResearchMeSH KeywordsADP-Ribosylation FactorsAdultAgedAged, 80 and overAtaxia Telangiectasia Mutated ProteinsCell Cycle ProteinsCyclin D1Cyclin-Dependent Kinase Inhibitor p16DNA-Binding ProteinsFemaleGene Expression ProfilingGenes, NeoplasmHumansLymphoma, Mantle-CellMaleMiddle AgedNeoplasm ProteinsPrognosisProtein Serine-Threonine KinasesReverse Transcriptase Polymerase Chain ReactionRNA, MessengerRNA, NeoplasmSurvival RateTumor Suppressor Protein p53Tumor Suppressor ProteinsUntranslated RegionsConceptsMantle cell lymphoma