Chloride channels regulate differentiation and barrier functions of the mammalian airway
He M, Wu B, Ye W, Le DD, Sinclair AW, Padovano V, Chen Y, Li KX, Sit R, Tan M, Caplan MJ, Neff N, Jan YN, Darmanis S, Jan LY. Chloride channels regulate differentiation and barrier functions of the mammalian airway. ELife 2020, 9: e53085. PMID: 32286221, PMCID: PMC7182432, DOI: 10.7554/elife.53085.Peer-Reviewed Original ResearchConceptsChloride channelsSingle-cell RNA sequencingNon-redundant roleCellular programsCellular landscapeRNA sequencingMolecular eventsEpithelial progenitorsGenetic inactivationMucosal barrierAirway barrier functionDevelopmental landscapeBarrier functionAbnormal mucociliary clearanceMammalian airwaysProtective mucosal barrierAirway mucosal barrierHuman fetal developmentPrimary targetAirway formationAirway disordersAirway diseaseAirway defectsMucus obstructionMouse airways