2023
Low-dose Initiation of Buprenorphine in Hospitalized Patients Using Buccal Buprenorphine: A Case Series
Adams K, Cohen S, Guerra M, Weimer M. Low-dose Initiation of Buprenorphine in Hospitalized Patients Using Buccal Buprenorphine: A Case Series. Journal Of Addiction Medicine 2023, 17: 474-476. PMID: 37579114, DOI: 10.1097/adm.0000000000001146.Peer-Reviewed Original ResearchConceptsOpioid use disorderBuprenorphine initiationSublingual buprenorphineChronic painBuccal buprenorphineCase seriesClinical Opiate Withdrawal Scale (COWS) scoresAddiction medicine serviceLow dose initiationSevere opioid withdrawalHistory of heroinOutpatient opioidsOpioid withdrawalAcute painFentanyl useHospitalized patientsMedian lengthPrescription refillsMedian numberModerate withdrawalInitiation strategiesBuprenorphineMedicine servicePatientsUse disorders
2022
Management of opioid use disorder, opioid withdrawal, and opioid overdose prevention in hospitalized adults: A systematic review of existing guidelines
Calcaterra SL, Bottner R, Martin M, Englander H, Weinstein ZM, Weimer MB, Lambert E, Ronan MV, Huerta S, Zaman T, Ullal M, Peterkin AF, Torres‐Lockhart K, Buresh M, O'Brien MT, Snyder H, Herzig SJ. Management of opioid use disorder, opioid withdrawal, and opioid overdose prevention in hospitalized adults: A systematic review of existing guidelines. Journal Of Hospital Medicine 2022, 17: 679-692. PMID: 35880821, PMCID: PMC9474657, DOI: 10.1002/jhm.12908.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsOpioid overdose preventionOpioid withdrawalOpioid useOUD treatmentOverdose preventionShort-acting opioid analgesicsOpioid use disorder managementAcute pain managementUse of methadoneOpioid use disorderEvaluation II (AGREE II) instrumentAppraisal of GuidelinesOpioid withdrawal managementUse of multimodalOpioid overdose reversalMethadone initiationNonopioid therapyHospitalized adultsBuprenorphine treatmentOpioid analgesicsPain managementTreatment guidelinesDiagnostic Statistical ManualOvid MEDLINEEdition criteria
2014
Research Gaps on Methadone Harms and Comparative Harms: Findings From a Review of the Evidence for an American Pain Society and College on Problems of Drug Dependence Clinical Practice Guideline
Weimer MB, Chou R. Research Gaps on Methadone Harms and Comparative Harms: Findings From a Review of the Evidence for an American Pain Society and College on Problems of Drug Dependence Clinical Practice Guideline. Journal Of Pain 2014, 15: 366-376. PMID: 24685460, DOI: 10.1016/j.jpain.2014.01.496.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAmerican Pain SocietyClinical practice guidelinesMethadone safetyPain SocietyAdverse eventsPractice guidelinesInsufficient evidenceEvidence-based clinical practice guidelinesSystematic reviewDependence Clinical Practice GuidelineMost guideline recommendationsTitration of therapyProlonged QTc intervalUrine drug testingLack of evidenceMethadone useGuideline recommendationsQTc intervalCochrane LibrarySafe prescribingRisk factorsUpdate searchOvid MEDLINEInclusion criteriaMethadone prescribingMethadone Overdose and Cardiac Arrhythmia Potential: Findings From a Review of the Evidence for an American Pain Society and College on Problems of Drug Dependence Clinical Practice Guideline
Chou R, Weimer MB, Dana T. Methadone Overdose and Cardiac Arrhythmia Potential: Findings From a Review of the Evidence for an American Pain Society and College on Problems of Drug Dependence Clinical Practice Guideline. Journal Of Pain 2014, 15: 338-365. PMID: 24685459, DOI: 10.1016/j.jpain.2014.01.495.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAmerican Pain SocietyMethadone useChronic painPain SocietyClinical guidelinesArrhythmia potentialDependence Clinical Practice GuidelineMethadone-related deathsQTc interval prolongationUse of methadoneClinical practice guidelinesCardiac arrhythmia riskMarked increaseNumber of deathsMethadone safetyMortality benefitCardiac riskInterval prolongationOpioid dependenceQTc intervalAdverse outcomesCochrane LibraryMethadone overdoseCase reportPsychiatric admissions
2013
Patterns of care and side effects for patients prescribed methadone for treatment of chronic pain.
Macey TA, Weimer MB, Grimaldi EM, Dobscha SK, Morasco BJ. Patterns of care and side effects for patients prescribed methadone for treatment of chronic pain. Journal Of Opioid Management 2013, 9: 325-33. PMID: 24353045, PMCID: PMC4001870, DOI: 10.5055/jom.2013.0175.Peer-Reviewed Original ResearchConceptsChronic painSide effectsSingle VA medical centerInitiation of methadoneInsufficient pain reliefCardiac side effectsChronic pain patientsHealth service utilizationPatterns of careMedical record dataVA Medical CenterNew initiationOpioid initiationPain reliefPain patientsQTc prolongationSustained releaseService utilizationClinical dataClinical significanceMedical CenterCalendar year 2008PatientsClinical information systemsMethadone
2011
The Source of Methadone in Overdose Deaths in Western Virginia in 2004
Weimer MB, Korthuis PT, Behonick GS, Wunsch MJ. The Source of Methadone in Overdose Deaths in Western Virginia in 2004. Journal Of Addiction Medicine 2011, 5: 188-202. PMID: 21844834, PMCID: PMC3156987, DOI: 10.1097/adm.0b013e318211c56a.Peer-Reviewed Original ResearchConceptsSource of methadoneOpioid treatment programsMethadone-related deathsOverdose deathsMethadone-related overdose deathsUnintentional poisoning deathsPrescription monitoring programsMajority of deathsCause of deathMedical examiner casesIllicit methadone useChief Medical ExaminerMethadone usePrescription opioidsPoisoning deathsNonprescription useMethadoneTreatment programNonmedical useDeathDecedentsMedical examinersRural VirginiaCurrent studyAnalgesia