2015
Clinical consequences and economic costs of untreated obstructive sleep apnea syndrome
Knauert M, Naik S, Gillespie MB, Kryger M. Clinical consequences and economic costs of untreated obstructive sleep apnea syndrome. World Journal Of Otorhinolaryngology - Head And Neck Surgery 2015, 1: 17-27. PMID: 29204536, PMCID: PMC5698527, DOI: 10.1016/j.wjorl.2015.08.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsObstructive sleep apnea syndromeSleep apnea syndromeUntreated obstructive sleep apnea syndromeApnea syndromeEffective therapyPoor patient acceptanceStart date restrictionLack of diagnosisSignificant economic burdenEnglish-language studiesExcessive daytimeSleep apneaPatient acceptanceCardiovascular diseaseClinical consequencesDate restrictionsEconomic burdenMetabolic diseasesPubMed databaseAbnormal physiologySyndromeTherapyLack of accessDiseaseTreatment
2012
Respiratory Event Detection by a Positive Airway Pressure Device
Berry RB, Kushida CA, Kryger MH, Soto-Calderon H, Staley B, Kuna ST. Respiratory Event Detection by a Positive Airway Pressure Device. Sleep 2012, 35: 361-367. PMID: 22379242, PMCID: PMC3274337, DOI: 10.5665/sleep.1696.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaEvents/hrPositive airway pressure devicesApnea indexHypopnea indexPAP devicesRespiratory eventsSleep disorders centerPressure deviceBetter treatment efficacyRespiratory event detectionOxygen desaturationSleep apneaPAP treatmentBland-Altman analysisDisorders CenterPolysomnographyTreatment efficacyAHIInadequate treatmentManual scoringHypopnea detectionTrue negative eventsHrTreatment
2007
Obstructive Sleep Apnea in Pregnancy
Kapsimalis F, Kryger M. Obstructive Sleep Apnea in Pregnancy. Sleep Medicine Clinics 2007, 2: 603-613. DOI: 10.1016/j.jsmc.2007.07.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsObstructive sleep apnea syndromeSleep-disordered breathingPregnant womenTreatment of OSASDiagnosis of OSASTreatment of SDBObese pregnant womenComplications of pregnancyOutcome of pregnancyObstructive sleep apneaSleep apnea syndromeManagement of pregnancyApnea syndromeSleep apneaHormonal alterationsFetal healthEarly recognitionHigh indexPregnancyNormal sleepRespiratory systemWomenTreatmentHypertensionApnea
2001
The Use of Health-Care Resources in Obesity-Hypoventilation Syndrome
Berg G, Delaive K, Manfreda J, Walld R, Kryger M. The Use of Health-Care Resources in Obesity-Hypoventilation Syndrome. CHEST Journal 2001, 120: 377-383. PMID: 11502632, DOI: 10.1378/chest.120.2.377.Peer-Reviewed Original ResearchConceptsGeneral population control subjectsObese control subjectsObesity hypoventilation syndromeInitiation of treatmentOHS patientsControl subjectsRetrospective observational cohort studyObservational cohort studyMeasurement of BMISleep breathing disordersHealth care utilizationPopulation control subjectsSleep disorders centerHealth care resourcesCohort studyPhysician visitsBreathing disordersDisorders CenterPatientsControl groupDiagnosisPhysician feesHealth careVisitsTreatment
1999
Health Care Utilization in Males with Obstructive Sleep Apnea Syndrome Two Years After Diagnosis and Treatment
Bahammam A, Delaive K, Ronald J, Manfreda J, Roos L, Kryger M. Health Care Utilization in Males with Obstructive Sleep Apnea Syndrome Two Years After Diagnosis and Treatment. Sleep 1999, 22: 740-747. PMID: 10505819, DOI: 10.1093/sleep/22.6.740.Peer-Reviewed Original ResearchConceptsOSA patientsGeneral populationProspective observational cohort studyObservational cohort studySubgroup of patientsSleep disorders centerTreatment of patientsTwo yearsOSAS groupCohort studyPAT groupControl subjectsDisorders CenterPhysician claimsPatientsUtilization dataOne-yearDiagnosisYears one yearTreatmentYearsCanadian provincesOSASGroupHospital
1995
Medical treatment of sleep apnea
Wali S, Kryger M. Medical treatment of sleep apnea. Current Opinion In Pulmonary Medicine 1995, 1: 498-503. PMID: 9363089, DOI: 10.1097/00063198-199511000-00012.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSleep apneaContinuous positive airway pressure therapyPositive airway pressure therapyContinuous positive airway pressureAirway pressure therapyPositive airway pressureObstructive sleep apneaCurrent treatment optionsTreatment of choiceAirway pressureNicotine treatmentPressure therapyTreatment optionsCommon disorderMedical treatmentDifficult patientsElectrical stimulationWeight lossDental appliancesApneaTherapyTreatmentUnwanted effectsTracheostomyPatients
1994
Acute Effect of Nasal CPAP on Periodic Limb Movements Associated with Breathing Disorders During Sleep
Yamashiro Y, Kryger M. Acute Effect of Nasal CPAP on Periodic Limb Movements Associated with Breathing Disorders During Sleep. Sleep 1994, 17: 172-175. PMID: 8036372, DOI: 10.1093/sleep/17.2.172.Peer-Reviewed Original ResearchConceptsNasal continuous positive airway pressurePeriodic limb movementsSleep-disordered breathingPLMS indexAcute effectsContinuous positive airway pressureLimb movementsSplit-night protocolPositive airway pressureNCPAP treatmentNasal CPAPAirway pressureBreathing disordersBreathingTreatmentFuture investigationsApneaCPAPPatientsSleep
1993
Nocturnal Cluster Headache Associated with Sleep Apnea. A Case Report
Buckle P, Kerr P, Kryger M. Nocturnal Cluster Headache Associated with Sleep Apnea. A Case Report. Sleep 1993, 16: 487-489. PMID: 8378690, DOI: 10.1093/sleep/16.5.487.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaCluster headacheRapid eye movement (REM) sleepChronic cluster headacheEye movement sleepNasal CPAPOxygen desaturationCase reportMovement sleepHeadache AssociatedBackup rateREM sleepTypical headacheHeadacheApneaSleep labFurther treatmentSleepDesaturationTreatmentBiPAPCPAPMedications
1992
MANAGEMENT OF OBSTRUCTIVE SLEEP APNEA
Kryger M. MANAGEMENT OF OBSTRUCTIVE SLEEP APNEA. Clinics In Chest Medicine 1992, 13: 481-492. PMID: 1521414, DOI: 10.1016/s0272-5231(21)00875-3.Peer-Reviewed Original ResearchConceptsPositive airway pressureObstructive sleep apneaAirway pressureSleep apneaNasal continuous positive airway pressureBilevel positive airway pressureContinuous positive airway pressureGeneral therapeutic measuresUpper airway abnormalitiesMinority of patientsLong-term efficacyHours of sleepHypopnea frequencyAirway abnormalitiesObese patientsSurgical managementDrug therapyTherapeutic measuresEffective treatmentPatientsSpecific abnormalitiesApneaWeight lossTreatmentAbnormalities
1991
Sleep quality in children with asthma treated with theophylline or cromolyn sodium
Avital A, Steljes D, Pasterkamp H, Kryger M, Sanchez I, Chernick V. Sleep quality in children with asthma treated with theophylline or cromolyn sodium. The Journal Of Pediatrics 1991, 119: 979-984. PMID: 1960623, DOI: 10.1016/s0022-3476(05)83062-8.Peer-Reviewed Original ResearchConceptsCromolyn sodiumTheophylline periodPlacebo-controlled trialArterial oxygen desaturationTheophylline blood levelsArterial oxygen saturationTotal sleep timeYears of ageOxygen desaturationPulmonary functionTheophylline treatmentBlood levelsChild's asthmaCentral originSleep latencyProtective effectSleep qualityOxygen saturationSleep efficiencySleep timeAsthmaMicrograms/SleepMovement timeTreatment
1983
The role of protriptyline in obstructive sleep apnea.
Brownell L, Perez-Padilla R, West P, Kryger M. The role of protriptyline in obstructive sleep apnea. European Respiratory Journal 1983, 19: 621-4. PMID: 6360257.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaTreatment of mildLong-term treatmentTricyclic agentsObese patientsObstructive apneaClinical statusCrossover trialImproved oxygenationInvasive treatmentTerm treatmentPatientsApneaArousal frequencySomnolenceProtriptylineTreatmentTrialsOxygenationREMTherapyMildMonths
1982
Protriptyline in Obstructive Sleep Apnea — A Double-Blind Trial
Brownell L, West P, Sweatman P, Acres J, Kryger M. Protriptyline in Obstructive Sleep Apnea — A Double-Blind Trial. New England Journal Of Medicine 1982, 307: 1037-1042. PMID: 6750396, DOI: 10.1056/nejm198210213071701.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaTotal sleep timeApnea timeApnea durationBody weightSleep timeDouble-blind crossover studyDouble-blind trialMonths of treatmentWeeks of treatmentNocturnal oxygenationREM reductionDaytime somnolenceCrossover studyTricyclic antidepressantsApneaArousal frequencySimilar decreaseProtriptylineSimilar improvementsTreatmentOxygenationDurationSomnolence