2002
Diagnoses Received by Narcolepsy Patients in the Year Prior to Diagnosis by a Sleep Specialist
Kryger M, Walld R, Manfreda J. Diagnoses Received by Narcolepsy Patients in the Year Prior to Diagnosis by a Sleep Specialist. Sleep 2002, 25: 36-41. PMID: 11833859, DOI: 10.1093/sleep/25.1.36.Peer-Reviewed Original ResearchConceptsOnset of symptomsSleep disorders centerCorrect diagnosisNarcolepsy patientsDisorders CenterManitoba Health databaseDiagnosis of narcolepsyNervous system disordersLonger intervalsClinical featuresExcessive daytimeNarcolepsy diagnosisNeurologic conditionsControl subjectsHypnagogic hallucinationsGeneral practitionersNeurologic disordersTeaching hospitalDoctor visitsNocturnal sleepSevere symptomatologySystem disordersGeneral populationSleep specialistsSpecialist evaluation
1997
Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy
Broughton R, Fleming J, George C, Hill J, Kryger M, Moldofsky H, Montplaisir J, Morehouse R, Moscovitch A, Murphy W. Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy. Neurology 1997, 49: 444-451. PMID: 9270575, DOI: 10.1212/wnl.49.2.444.Peer-Reviewed Original ResearchConceptsPlacebo-controlled crossover trialOnly significant adverse effectPlacebo-controlled trialExcessive daytime somnolenceMean sleep latencyPeriodic leg movementsEpworth Sleepiness ScaleDaytime sleep episodesInternational diagnostic criteriaSignificant adverse effectsHypertensive patientsMore nauseaBlood pressureDaily doseDaytime somnolenceExcessive daytimeSleep apneaCrossover trialSleep latencyModafinil 200Nocturnal sleepPatient's abilitySleepiness ScaleSleep initiationHeart rate