2009
Evidence‐Based Recommendations for the Assessment and Management of Sleep Disorders in Older Persons
Bloom HG, Ahmed I, Alessi CA, Ancoli‐Israel S, Buysse DJ, Kryger MH, Phillips BA, Thorpy MJ, Vitiello MV, Zee PC. Evidence‐Based Recommendations for the Assessment and Management of Sleep Disorders in Older Persons. Journal Of The American Geriatrics Society 2009, 57: 761-789. PMID: 19484833, PMCID: PMC2748127, DOI: 10.1111/j.1532-5415.2009.02220.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSpecific sleep disordersSleep disordersExpert-based recommendationsOlder personsRestless legs syndromeCircadian rhythm sleep disordersEvidence-based recommendationsSleep-related disordersPatient care practicesSerious medical problemTerm care settingsOlder adult populationMultiple medicationsPsychosocial comorbiditiesLegs syndromeSleep apneaCerebrovascular diseaseStrong bidirectional relationshipCardiovascular diseaseHigh prevalenceCare settingsSleep problemsHigh riskAmbulatory settingCare practices
2005
Sleep disorders in older people
Banno K, Kryger M. Sleep disorders in older people. Aging Health 2005, 1: 449-457. DOI: 10.2217/1745509x.1.3.449.Peer-Reviewed Original ResearchSleep disordersObstructive sleep apnea syndromeOlder peopleAge-related medical conditionsSleep apnea syndromeRestless legs syndromeFrequent nocturnal awakeningsCommon sleep disorderQuality of lifeSleep onset insomniaObstructive sleepApnea syndromeNeuropsychiatric functionRestless legsLegs syndromeImpaired qualityNocturnal awakeningsUpper airwayAnatomic changesCognitive dysfunctionMedical conditionsSleep pathologyPsychiatric conditionsNeuropsychiatric disordersPatient health
2002
Low body stores of iron and restless legs syndrome: a correctable cause of insomnia in adolescents and teenagers
Kryger MH, Otake K, Foerster J. Low body stores of iron and restless legs syndrome: a correctable cause of insomnia in adolescents and teenagers. Sleep Medicine 2002, 3: 127-132. PMID: 14592231, DOI: 10.1016/s1389-9457(01)00160-5.Peer-Reviewed Original ResearchRestless legs syndromePercent iron saturationIron storesSubjective sleep latencyFerritin levelsLegs syndromeSleep latencySymptoms of RLSBody storesLow serum ferritin levelsTotal iron binding capacitySerum ferritin levelsSevere sleep onset insomniaLow body storesIron binding capacityHours of sleepSleep onset insomniaOral ironCorrectable causeExcessive daytimeSerum ferritinChronic insomniaSerum ironIron statusOnset insomnia
2001
Sleep complaints and restless legs syndrome in adult type 2 diabetics
Skomro R, Ludwig S, Salamon E, Kryger M. Sleep complaints and restless legs syndrome in adult type 2 diabetics. Sleep Medicine 2001, 2: 417-422. PMID: 14592391, DOI: 10.1016/s1389-9457(01)00110-1.Peer-Reviewed Original ResearchRestless legs syndromeAdult type 2 diabeticsType 2 diabeticsAdult diabeticsLegs syndromeSleep complaintsPresence of RLSPrevalence of RLSConsecutive type 2 diabetic patientsType 2 Adult DiabeticsType 2 diabetic patientsEpworth Sleepiness ScoreProportion of diabeticsCauses of insomniaHigh rateSensory polyneuropathyCreatinine levelsExcessive somnolenceDaytime somnolenceDiabetes mellitusDiabetic patientsHypnotic useSensory neuropathyDiabetes controlSleep Questionnaire
2000
Restless legs syndrome in 218 patients: associated disorders
Banno K, Delaive K, Walld R, Kryger M. Restless legs syndrome in 218 patients: associated disorders. Sleep Medicine 2000, 1: 221-229. PMID: 10828433, DOI: 10.1016/s1389-9457(00)00023-x.Peer-Reviewed Original ResearchRestless legs syndromeRLS patientsFemale controlsMale controlsMale patientsFemale patientsManitoba Health databasePeriodic limb movementsSleep laboratory evaluationSleep maintenance insomniaDiseases of jointsMost patientsExtrapyramidal diseasesRestless legsExtrapyramidal disordersLegs syndromePainful conditionsControl subjectsMaintenance insomniaMovement disordersGeneral populationPsychiatric disordersMusculoskeletal disordersPatientsHealth databases
1998
Effect of Pergolide on Restless Legs and Leg Movements in Sleep in Uremic Patients
Pieta J, Miliar T, Zacharias J, Fine A, Kryger M. Effect of Pergolide on Restless Legs and Leg Movements in Sleep in Uremic Patients. Sleep 1998, 21: 617-622. PMID: 9779521, DOI: 10.1093/sleep/21.6.617.Peer-Reviewed Original ResearchConceptsRestless legs syndromeLeg movementsRestless legsUremic patientsSubjective improvementTreatment of RLSDouble-blind placebo-controlled crossover studyPlacebo-controlled crossover studyRestless legs symptomsEffects of pergolideContinuous peritoneal dialysisPeriodic limb movementsSmall patient groupsHours of sleepQuality of sleepFirst hourChronic hemodialysisLeg symptomsCrossover studyLegs syndromePeritoneal dialysisIncremental dosesPatient groupSleep architectureSleep disruption
1996
L-DOPA/Carbidopa for Nocturnal Movement Disorders in Uremia
Walker S, Fine A, Kryger M. L-DOPA/Carbidopa for Nocturnal Movement Disorders in Uremia. Sleep 1996, 19: 214-218. PMID: 8723378, DOI: 10.1093/sleep/19.3.214.Peer-Reviewed Original ResearchConceptsL-dopa/carbidopaRestless legs syndromeSlow-wave sleepLeg movementsSleep timeTreatment of RLSMovement arousal indexNocturnal movement disordersSingle bedtime doseChronic hemodialysis patientsPeriodic limb movementsHours of sleepBedtime doseActive medicationHemodialysis patientsCrossover studyLegs syndromeUremic patientsArousal indexMovement disordersSleep disruptionFrequent dosingObjective improvementSleep disordersEffective treatment
1995
Sleep complaints are common in a dialysis unit
Walker S, Fine A, Kryger M. Sleep complaints are common in a dialysis unit. American Journal Of Kidney Diseases 1995, 26: 751-756. PMID: 7485127, DOI: 10.1016/0272-6386(95)90438-7.Peer-Reviewed Original ResearchConceptsRestless legs syndromeSleep-wake complaintsSpecific sleep disordersCreatinine levelsDialysis patientsLegs syndromeSleep apneaUremic patientsFrequent awakeningsImpaired qualitySleep complaintsSleep QuestionnaireHemodialysis unitDaytime sleepinessDisturbed sleepMale genderDialysis unitsCaffeine intakeClinical significanceSleep disordersSleep problemsFrequent complaintPatientsSpecific complaintsActual prevalenceA Familial Awake Movement Disorder Mimicking Restless Legs in a Sleep Apnea Patient
Yamashiro Y, Chodirker B, Hobson D, Kryger M. A Familial Awake Movement Disorder Mimicking Restless Legs in a Sleep Apnea Patient. Sleep 1995, 18: 604-607. PMID: 8552932, DOI: 10.1093/sleep/18.7.604.Peer-Reviewed Original ResearchConceptsRestless legs syndromeMovement disordersFamilial movement disordersLegs syndromeSleep apneaNasal continuous positive airway pressureContinuous positive airway pressurePositive airway pressureObstructive sleep apneaPeriodic limb movementsSleep apnea syndromeSleep apnea patientsSleep onset insomniaSupine posturingAirway pressureObese menApnea syndromeLeg sensationsRestless legsNocturnal arousalsMean durationApnea patientsDaytime sleepinessSuccessful treatmentClinical significance