1988
Identification and Quantification of Apneas by Computer-based Analysis of Oxygen Saturation
George C, Millar T, Kryger M. Identification and Quantification of Apneas by Computer-based Analysis of Oxygen Saturation. American Journal Of Respiratory And Critical Care Medicine 1988, 137: 1238-1240. PMID: 3195821, DOI: 10.1164/ajrccm/137.5.1238.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexApnea-hypopnea eventsNight polysomnogramsObstructive sleep apneaSleep apneaOvernight studyOxygen saturationSaO2 changesPredictive valueFalse negative rateApneaApnea eventsPolysomnogramSaO2 dataMethod of detectionOverall numberDurationNegative rateTotal numberManual scoringSaO2Patients
1982
Protriptyline in Obstructive Sleep Apnea — A Double-Blind Trial
Brownell L, West P, Sweatman P, Acres J, Kryger M. Protriptyline in Obstructive Sleep Apnea — A Double-Blind Trial. New England Journal Of Medicine 1982, 307: 1037-1042. PMID: 6750396, DOI: 10.1056/nejm198210213071701.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaTotal sleep timeApnea timeApnea durationBody weightSleep timeDouble-blind crossover studyDouble-blind trialMonths of treatmentWeeks of treatmentNocturnal oxygenationREM reductionDaytime somnolenceCrossover studyTricyclic antidepressantsApneaArousal frequencySimilar decreaseProtriptylineSimilar improvementsTreatmentOxygenationDurationSomnolence