Extracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis
Ma Z, Sun Y, Yu Y, Xiao W, Xiao Z, Zhong T, Xiang X, Li Z. Extracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis. Cell Communication And Signaling 2024, 22: 295. PMID: 38802814, PMCID: PMC11131254, DOI: 10.1186/s12964-024-01669-9.Peer-Reviewed Original ResearchConceptsProteomic analysisExtracellular vesiclesSignaling pathwayCRC cell linesFlow cytometric analysisMacrophage efferocytosisCRC cellsClear apoptotic cellsCell linesMass spectrometry-based proteomic analysisCRISPR-Cas9 gene editing systemCytometric analysisInvolvement of extracellular vesiclesEfferocytosis in vitroCancer Genome AtlasGene editing systemTumor microenvironmentCRISPR-Cas9Apoptotic cellsCell surfacePromotion of drug resistanceMFGE8Genome AtlasProtein moleculesEditing systemTumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives
Wang L, Wang W, Hu D, Liang Y, Liu Z, Zhong T, Wang X. Tumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives. Frontiers In Immunology 2024, 15: 1346587. PMID: 38690261, PMCID: PMC11058222, DOI: 10.3389/fimmu.2024.1346587.Peer-Reviewed Original ResearchConceptsTumor-derived extracellular vesiclesTumor developmentBreast carcinomaLung carcinomaExtracellular vesiclesM2 phenotypeMacrophage polarizationM2 polarizationPromote tumor developmentStimulate macrophage polarizationAnti-tumor activityM2 to M1 macrophagesAnti-inflammatory effectsInduced M2 polarizationPancreatic carcinomaPro-tumorColorectal carcinomaTumor progressionHepatocellular carcinomaCarcinomaColorectal cancerRegulating tumor developmentCell ratioM1 macrophagesPromote M2 polarization