Therapeutic potential of extracellular vesicles from diverse sources in cancer treatment
Lin H, Zhou J, Ding T, Zhu Y, Wang L, Zhong T, Wang X. Therapeutic potential of extracellular vesicles from diverse sources in cancer treatment. European Journal Of Medical Research 2024, 29: 350. PMID: 38943222, PMCID: PMC11212438, DOI: 10.1186/s40001-024-01937-x.Peer-Reviewed Original ResearchConceptsPotential of extracellular vesiclesExtracellular vesiclesTumor growthDissemination of primary tumorsCancer treatmentBiological characteristics of extracellular vesiclesTherapeutic potential of extracellular vesiclesRegulate tumor growthEffective cancer treatmentCharacteristics of extracellular vesiclesCytoplasmic proteinsEngineered extracellular vesiclesPrimary tumorComplex diseasesDistant organsCancer therapyCancer developmentCell differentiationImmune responseInfluence cancerCancerTherapeutic potentialIntercellular communicationExcessive proliferationOncogenic factorTumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives
Wang L, Wang W, Hu D, Liang Y, Liu Z, Zhong T, Wang X. Tumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives. Frontiers In Immunology 2024, 15: 1346587. PMID: 38690261, PMCID: PMC11058222, DOI: 10.3389/fimmu.2024.1346587.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CommunicationCytokinesExtracellular VesiclesHumansMacrophage ActivationMacrophagesNeoplasmsTumor MicroenvironmentConceptsTumor-derived extracellular vesiclesTumor developmentBreast carcinomaLung carcinomaExtracellular vesiclesM2 phenotypeMacrophage polarizationM2 polarizationPromote tumor developmentStimulate macrophage polarizationAnti-tumor activityM2 to M1 macrophagesAnti-inflammatory effectsInduced M2 polarizationPancreatic carcinomaPro-tumorColorectal carcinomaTumor progressionHepatocellular carcinomaCarcinomaColorectal cancerRegulating tumor developmentCell ratioM1 macrophagesPromote M2 polarization