Small extracellular vesicles promote the formation of the pre-metastatic niche through multiple mechanisms in colorectal cancer
Wu J, Wang X, Li Z, Yi X, Hu D, Wang Q, Zhong T. Small extracellular vesicles promote the formation of the pre-metastatic niche through multiple mechanisms in colorectal cancer. Cell Cycle 2024, 23: 131-149. PMID: 38341861, PMCID: PMC11037293, DOI: 10.1080/15384101.2024.2311501.Peer-Reviewed Original ResearchPre-metastatic nicheEpithelial-to-mesenchymal transitionSmall extracellular vesiclesPre-metastatic niche formationExtracellular vesiclesStromal cell activationPromote immunosuppressionPromote lymphangiogenesisMetastatic potentialColorectal cancerVascular permeabilityMetastatic invasionCell activationInflammatory factorsGlobal malignancyUpregulated inflammatory factorsMultiple mechanismsPotential mechanismsRemodelingNetwork remodeling