Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6- and caspase-3-mediated mitochondrial apoptosis
Guo Q, Zhao M, Wang Q, Lu T, Luo P, Chen L, Xia F, Pang H, Shen S, Cheng G, Dai C, Meng Y, Zhong T, Qiu C, Wang J. Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6- and caspase-3-mediated mitochondrial apoptosis. Biomedicine & Pharmacotherapy 2024, 173: 116304. PMID: 38401519, DOI: 10.1016/j.biopha.2024.116304.Peer-Reviewed Original ResearchNon-small cell lung cancerCell lung cancerMitochondrial apoptosisActivity-based protein profilingLung cancerTreatment of non-small cell lung cancerGlycyrrhetinic acidInhibit non-small cell lung cancerCombination of histopathologyCaspase-3Proteomic validationTarget of GAIn vivo resultsProtein profilesPeroxiredoxin 6Clinical applicationIn vitroApoptosisPotential targetCancerPrdx6Application of GAPromoter