Tumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives
Wang L, Wang W, Hu D, Liang Y, Liu Z, Zhong T, Wang X. Tumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives. Frontiers In Immunology 2024, 15: 1346587. PMID: 38690261, PMCID: PMC11058222, DOI: 10.3389/fimmu.2024.1346587.Peer-Reviewed Original ResearchConceptsTumor-derived extracellular vesiclesTumor developmentBreast carcinomaLung carcinomaExtracellular vesiclesM2 phenotypeMacrophage polarizationM2 polarizationPromote tumor developmentStimulate macrophage polarizationAnti-tumor activityM2 to M1 macrophagesAnti-inflammatory effectsInduced M2 polarizationPancreatic carcinomaPro-tumorColorectal carcinomaTumor progressionHepatocellular carcinomaCarcinomaColorectal cancerRegulating tumor developmentCell ratioM1 macrophagesPromote M2 polarizationSmall extracellular vesicles promote the formation of the pre-metastatic niche through multiple mechanisms in colorectal cancer
Wu J, Wang X, Li Z, Yi X, Hu D, Wang Q, Zhong T. Small extracellular vesicles promote the formation of the pre-metastatic niche through multiple mechanisms in colorectal cancer. Cell Cycle 2024, 23: 131-149. PMID: 38341861, PMCID: PMC11037293, DOI: 10.1080/15384101.2024.2311501.Peer-Reviewed Original ResearchPre-metastatic nicheEpithelial-to-mesenchymal transitionSmall extracellular vesiclesPre-metastatic niche formationExtracellular vesiclesStromal cell activationPromote immunosuppressionPromote lymphangiogenesisMetastatic potentialColorectal cancerVascular permeabilityMetastatic invasionCell activationInflammatory factorsGlobal malignancyUpregulated inflammatory factorsMultiple mechanismsPotential mechanismsRemodelingNetwork remodeling