2015
MHC class II-disparate heart but not skin allografts accelerate recipient cardiovascular disease (TRAN1P.934)
Zhou J, yi T, Qin L, Ali R, Li Q, Jiao Y, Li G, Zhang J, Sadeghi M, Pober J, Tellides G. MHC class II-disparate heart but not skin allografts accelerate recipient cardiovascular disease (TRAN1P.934). The Journal Of Immunology 2015, 194: 140.16-140.16. DOI: 10.4049/jimmunol.194.supp.140.16.Peer-Reviewed Original ResearchSkin allograftsCardiovascular diseaseAllograft rejectionCardiac allograftsHeart allograftsDonor miceSkin graftsMHC classAtherosclerotic lesionsApoE-/- mouse modelEarly activation marker CD69End-stage organ failureCD4 T cellsWeeks post transplantationActivation marker CD69Larger atherosclerotic lesionsHeart isograftsCardiac isograftsOrgan failurePost transplantationIL-12ACardiac functionElevated mRNA levelsEffective therapyOrgan transplantation
2004
Vascular cell adhesion molecule-1-targeted detection of endothelial activation in human microvasculature
Sadeghi MM, Schechner JS, Krassilnikova S, Gharaei AA, Zhang J, Kirkiles-Smith N, Sinusas AJ, Zaret BL, Bender JR. Vascular cell adhesion molecule-1-targeted detection of endothelial activation in human microvasculature. Transplantation Proceedings 2004, 36: 1585-1591. PMID: 15251390, DOI: 10.1016/j.transproceed.2004.05.060.Peer-Reviewed Original ResearchConceptsChimeric human/mouse modelHuman/mouse modelHuman skin graftsEndothelial activationSkin graftsEndothelial cellsMouse modelIsotype-matched control antibodySCID/beige miceTumor necrosis factorEndothelial adhesion moleculesMurine VCAM-1Murine red blood cellsRed blood cellsHuman endothelial cellsControl antibodyInflammatory responseNecrosis factorBeige miceTc-99mVCAM-1Tissue vascularityMonoclonal antibodiesBlood cellsAdhesion molecules