Clipping the Positive Lymph Node in Patients with Clinically Node Positive Breast Cancer Treated with Neoadjuvant Chemotherapy: Impact on Axillary Surgery in the ISPY-2 Clinical Trial
Switalla K, Boughey J, Dimitroff K, Yau C, Ladores V, Yu H, Tchou J, Golshan M, Ahrendt G, Postlewait L, Piltin M, Reyna C, Matsen C, Tuttle T, Wallace A, Arciero C, Lee M, Tseng J, Son J, Rao R, Sauder C, Naik A, Howard-McNatt M, Lancaster R, Norwood P, Esserman L, Mukhtar R. Clipping the Positive Lymph Node in Patients with Clinically Node Positive Breast Cancer Treated with Neoadjuvant Chemotherapy: Impact on Axillary Surgery in the ISPY-2 Clinical Trial. Annals Of Surgical Oncology 2024, 31: 7249-7259. PMID: 38995451, PMCID: PMC11452431, DOI: 10.1245/s10434-024-15792-x.Peer-Reviewed Original ResearchPositive lymph nodesEvent-free survivalNeoadjuvant chemotherapyAxillary surgeryClip placementLymph nodesPN+ diseasePositive nodesNode-positive breast cancer treated with neoadjuvant chemotherapyBreast cancer treated with neoadjuvant chemotherapyOmission of axillary dissectionSentinel lymph node biopsyClinically node-positiveNeoadjuvant chemotherapy trialsPathologically node-positiveLymph node biopsySurgical management strategiesProportion of patientsMultivariate logistic regressionNode-positiveAssociated with higher oddsCN+ patientsPre-NACNode biopsyAxillary dissection