2019
Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use
Carroll KM, DeVito EE, Yip SW, Nich C, Sofuoglu M. Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use. American Journal On Addictions 2019, 28: 238-245. PMID: 31165574, PMCID: PMC9078084, DOI: 10.1111/ajad.12904.Peer-Reviewed Original ResearchConceptsMethadone-maintained individualsOpioid useSecondary analysisMultiple drugsConcurrent cocaine dependenceTrial of galantaminePlacebo-controlled trialDouble-blind placeboIllicit opioid useRandomized clinical trialsCocaine use disorderGalantamine's effectFuture trialsClinical trialsUrine specimenUrine specimensUse disordersOpioidsCholinesterase inhibitorsMaintenance settingCocaine useCocaine dependencePlaceboConcurrent useGalantamine
2018
Minocycline does not affect experimental pain or addiction-related outcomes in opioid maintained patients
Arout CA, Waters AJ, MacLean RR, Compton P, Sofuoglu M. Minocycline does not affect experimental pain or addiction-related outcomes in opioid maintained patients. Psychopharmacology 2018, 236: 2857-2866. PMID: 30564869, PMCID: PMC6581631, DOI: 10.1007/s00213-018-5146-7.Peer-Reviewed Original ResearchConceptsOpioid-induced hyperalgesiaCold pressor testOpioid use disorderSerum cytokinesPain thresholdUse disordersAddiction-related outcomesProinflammatory serum cytokinesActivation of microgliaSeverity of painEcological momentary assessmentEnd of treatmentHuman laboratory studiesTest sessionsOpioid cravingMinocycline treatmentOpioid toleranceAgonist treatmentPain sensitivityVisit 1Minocycline effectsPressor testExperimental painPreclinical studiesGo/No-Go task
2012
Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine
Sofuoglu M, Herman AI, Nadim H, Jatlow P. Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine. Neuropsychopharmacology 2012, 37: 1509-1516. PMID: 22334123, PMCID: PMC3327855, DOI: 10.1038/npp.2011.336.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceCarbon MonoxideChi-Square DistributionChromatography, High Pressure LiquidCotinineDose-Response Relationship, DrugHeart RateHumansHydrocortisoneInjections, IntravenousMaleMiddle AgedNicotineNicotinic AgonistsSingle-Blind MethodSubstance Withdrawal SyndromeTandem Mass SpectrometryTime FactorsYoung AdultConceptsHigher nicotine metabolite ratioNicotine metabolite ratioHeart rate increaseCessation treatmentNicotine clearanceOvernight abstinenceGood drug effectBlood pressure measuresDiastolic blood pressure measuresEffects of nicotinePoor treatment responseNicotine dependence scoresTreatment-seeking smokersGreater heart rate increaseIntravenous dosesNicotine patchPoor outcomeNicotine rewardDrug likingFagerstrom TestTreatment outcomesIntravenous nicotineTreatment responseCigarette cravingHeart rate
2001
Depressive symptoms modulate the subjective and physiological response to cocaine in humans
Sofuoglu M, Brown S, Babb D, Hatsukami D. Depressive symptoms modulate the subjective and physiological response to cocaine in humans. Drug And Alcohol Dependence 2001, 63: 131-137. PMID: 11376917, DOI: 10.1016/s0376-8716(00)00199-x.Peer-Reviewed Original ResearchConceptsDepressive symptomsCocaine responseBeck Depression Inventory scoresHigher BDI groupLower BDI scoresDepression Inventory scoresSubclinical depressive symptomsBody weight differencesInpatient studyMajor depressionBDI scoresCocaine use behaviorBDI groupInventory scoresSymptomsCocaineCocaine usersPhysiological responsesGroup differencesEnhanced responseSubjective responsesWeight differencesScoresUse behaviorsResponse
2000
Individual Differences in the Subjective Response to Smoked Cocaine in Humans
Sofuoglu M, Brown S, Dudish-Poulsen S, Hatsukami D. Individual Differences in the Subjective Response to Smoked Cocaine in Humans. The American Journal Of Drug And Alcohol Abuse 2000, 26: 591-602. PMID: 11097194, DOI: 10.1081/ada-100101897.Peer-Reviewed Original ResearchConceptsHeart rateBaseline Beck Depression Inventory scoresSubjective responsesBeck Depression Inventory scoresDiastolic blood pressureCocaine deliveryEffects of cocaineDepression Inventory scoresCocaine-dependent participantsBlood pressureMale sexCocaine use behaviorBody weightCocaine useSmoked CocaineAlcohol useInventory scoresCocaineCocaine users
1999
Effects of phenytoin on cocaine self-administration in humans1Portions of this report were presented at the 59th Annual Scientific Meeting of the College on the Problems of Drug Dependence, Nashville, June 1997.1
Sofuoglu M, Pentel P, Bliss R, Goldman A, Hatsukami D. Effects of phenytoin on cocaine self-administration in humans1Portions of this report were presented at the 59th Annual Scientific Meeting of the College on the Problems of Drug Dependence, Nashville, June 1997.1. Drug And Alcohol Dependence 1999, 53: 273-275. PMID: 10080053, DOI: 10.1016/s0376-8716(98)00140-9.Peer-Reviewed Original ResearchConceptsEffects of phenytoinSingle oral loading doseOral loading dosePlacebo treatment groupsEffects of cocaineHuman laboratory modelLoading doseSignificant treatment effectCocaine administrationTreatment groupsDrug dependencePhenytoinPilot studyCocaineAnnual Scientific MeetingTreatment effectsSubjective responsesScientific meetingsPlacebo
1998
Effects of cotinine on cigarette self-administration
Hatsukami D, Lexau B, Nelson D, Pentel P, Sofuoglu M, Goldman A. Effects of cotinine on cigarette self-administration. Psychopharmacology 1998, 138: 184-189. PMID: 9718288, DOI: 10.1007/s002130050661.Peer-Reviewed Original ResearchConceptsDoses of cotinineWithdrawal symptomsCigarette withdrawal symptomsEffects of cotinineNicotine serum levelsSelective modulatory effectNicotine withdrawal symptomsNumber of cigarettesEffects of nicotineMetabolite of nicotineSubjective responsesNicotine patchSerum levelsCigarette smokingNicotine intakeModulatory effectsCarbon monoxide levelsCotinineRandomized orderPlaceboBeneficial effectsCigarettesOutcome variablesDosesSymptoms