2022
Plasma Menthol Glucuronide as a Biomarker for the Behavioral Effects of Menthol and Nicotine in Humans
Gueorguieva R, Schwartz EKC, MacLean RR, DeVito EE, Eid T, Wu R, O’Malley S, Sofuoglu M. Plasma Menthol Glucuronide as a Biomarker for the Behavioral Effects of Menthol and Nicotine in Humans. Frontiers In Pharmacology 2022, 13: 844824. PMID: 35431934, PMCID: PMC9009207, DOI: 10.3389/fphar.2022.844824.Peer-Reviewed Original ResearchSubjective drug effectsPlasma Mg concentrationHeart rateDrug effectsIntravenous deliveryNon-menthol cigarette smokersPlacebo-controlled studyTest sessionsCigarette smokersMenthol smokersAcute effectsIntravenous nicotineGlucuronide concentrationsMAIN OUTCOMENicotine infusionMenthol glucuronideSecondary analysisPlasma MgE-cigarettesBehavioral effectsMenthol exposureNicotineSmokersPhysiological effectsE-liquids
2015
Intravenous Nicotine Self-Administration in Smokers: Dose–Response Function and Sex Differences
Jensen KP, DeVito EE, Valentine G, Gueorguieva R, Sofuoglu M. Intravenous Nicotine Self-Administration in Smokers: Dose–Response Function and Sex Differences. Neuropsychopharmacology 2015, 41: 2034-2040. PMID: 26717881, PMCID: PMC4908640, DOI: 10.1038/npp.2015.373.Peer-Reviewed Original ResearchConceptsBlood pressureHeart rateFemale smokersRandomized double-blind crossover designDouble-blind crossover designSubjective effectsTobacco-dependent subjectsSex differencesDiastolic blood pressureIntravenous Nicotine Self-AdministrationSelf-administration ratesNicotine Self-AdministrationDose-response functionNicotine dosesNicotine doseTobacco dependenceIntravenous nicotineCrossover designSelf-AdministrationReinforcement thresholdSmokersInfusionNicotineForced-choice trialsAversive responses
2013
Chapter 35 Medications to Treat Addictions Nicotine Replacement
Herman A, Sofuoglu M. Chapter 35 Medications to Treat Addictions Nicotine Replacement. 2013, 337-343. DOI: 10.1016/b978-0-12-398338-1.00035-x.Peer-Reviewed Original ResearchNicotine replacement therapyTobacco addictionMajor public health problemNicotine deliveryPublic health problemMore effective treatmentsPatient-treatment matchingNRT formulationsPostpartum smokersNicotine replacementEffective medicationsReplacement therapySmoking cessationTobacco usageAdolescent smokersClinical guidanceEffective treatmentSmokersHealth problemsTreatment matchingMedicationsPromising findingsSmokingAddictionGreat need
2001
Progesterone treatment during the early follicular phase of the menstrual cycle: Effects on smoking behavior in women
Sofuoglu M, Babb D, Hatsukami D. Progesterone treatment during the early follicular phase of the menstrual cycle: Effects on smoking behavior in women. Pharmacology Biochemistry And Behavior 2001, 69: 299-304. PMID: 11420098, DOI: 10.1016/s0091-3057(01)00527-5.Peer-Reviewed Original ResearchConceptsEarly follicular phaseProgesterone treatmentFollicular phaseSmoking behaviorFemale smokersMenstrual cycleProgesterone levelsDose of progesteroneEffect of progesteroneSelf-administration periodMedication treatmentEndogenous estradiolExperimental sessionsExogenous progesteroneNicotine dependenceProgesteroneSubjective effectsSmokersTreatmentEstradiolSubjective responsesCigarettesSecond sessionSubjectsWomen