2024
Pulsed nicotine infusions as a model for smoking: validating a tool to explore nicotine thresholds in humans
Parida S, MacLean R, Gueorguieva R, Sofuoglu M. Pulsed nicotine infusions as a model for smoking: validating a tool to explore nicotine thresholds in humans. Psychopharmacology 2024, 241: 1915-1922. PMID: 38970644, DOI: 10.1007/s00213-024-06609-6.Peer-Reviewed Original ResearchDiscriminative stimulus effectsAddiction thresholdNicotine doseDiscriminative stimulus effects of nicotineStimulus effects of nicotineNicotine deliveryEffects of nicotineOvernight abstinenceStimulus effectsNicotine infusionSubjective effectsTest sessionsNicotineMethodsEleven participantsInfusion procedureLow dosesParticipantsThreshold doseConclusionsTheseAbstinenceDoseHeart rateInfusionSmokingObjectivesTo
2022
Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science
De Aquino JP, MacLean RR, Gueorguieva R, DeVito EE, Eid T, Sofuoglu M. Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science. Addiction Biology 2022, 27: e13161. PMID: 35229960, PMCID: PMC8903077, DOI: 10.1111/adb.13161.Peer-Reviewed Original ResearchConceptsAbuse potentialPositive subjective drug effectsSubjective drug effectsHuman laboratory studiesPositive subjective effectsAttention functionSmoking urgesOvernight abstinencePotential therapeutic effectsEffects of nicotineHeart rate increaseDelivery rateDependent smokersExperimental sessionsSubjective effectsNicotine dependenceIntravenous nicotineBlood pressureSaline infusionAcute effectsTherapeutic effectHeart rateDrug effectsAcute responseCrossover design
2014
Chapter Twelve Cognitive Effects of Nicotine
Sofuoglu M, Herman A, Robinson C, Waters A. Chapter Twelve Cognitive Effects of Nicotine. 2014, 367-385. DOI: 10.1016/b978-0-12-418679-8.00012-5.Peer-Reviewed Original ResearchCognitive-enhancing effectsPrefrontal cortexCognitive functionCognitive deficitsEpisodic memory performanceFine motor skillsNicotine addictionMemory performanceCognitive effectsMotor skillsEffects of nicotineIndividual factorsNicotine administrationFlexibility functionMemoryCortexDeficitsAddictionΑ7 nicotinic acetylcholine receptorEffective treatment strategiesNicotinic acetylcholine receptorsNicotineRelease of neurotransmittersΑ4β2Cigarette smoking
2012
Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine
Sofuoglu M, Herman AI, Nadim H, Jatlow P. Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine. Neuropsychopharmacology 2012, 37: 1509-1516. PMID: 22334123, PMCID: PMC3327855, DOI: 10.1038/npp.2011.336.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceCarbon MonoxideChi-Square DistributionChromatography, High Pressure LiquidCotinineDose-Response Relationship, DrugHeart RateHumansHydrocortisoneInjections, IntravenousMaleMiddle AgedNicotineNicotinic AgonistsSingle-Blind MethodSubstance Withdrawal SyndromeTandem Mass SpectrometryTime FactorsYoung AdultConceptsHigher nicotine metabolite ratioNicotine metabolite ratioHeart rate increaseCessation treatmentNicotine clearanceOvernight abstinenceGood drug effectBlood pressure measuresDiastolic blood pressure measuresEffects of nicotinePoor treatment responseNicotine dependence scoresTreatment-seeking smokersGreater heart rate increaseIntravenous dosesNicotine patchPoor outcomeNicotine rewardDrug likingFagerstrom TestTreatment outcomesIntravenous nicotineTreatment responseCigarette cravingHeart rate
1998
Effects of cotinine on cigarette self-administration
Hatsukami D, Lexau B, Nelson D, Pentel P, Sofuoglu M, Goldman A. Effects of cotinine on cigarette self-administration. Psychopharmacology 1998, 138: 184-189. PMID: 9718288, DOI: 10.1007/s002130050661.Peer-Reviewed Original ResearchConceptsDoses of cotinineWithdrawal symptomsCigarette withdrawal symptomsEffects of cotinineNicotine serum levelsSelective modulatory effectNicotine withdrawal symptomsNumber of cigarettesEffects of nicotineMetabolite of nicotineSubjective responsesNicotine patchSerum levelsCigarette smokingNicotine intakeModulatory effectsCarbon monoxide levelsCotinineRandomized orderPlaceboBeneficial effectsCigarettesOutcome variablesDosesSymptoms