2015
Intravenous Nicotine Self-Administration in Smokers: Dose–Response Function and Sex Differences
Jensen KP, DeVito EE, Valentine G, Gueorguieva R, Sofuoglu M. Intravenous Nicotine Self-Administration in Smokers: Dose–Response Function and Sex Differences. Neuropsychopharmacology 2015, 41: 2034-2040. PMID: 26717881, PMCID: PMC4908640, DOI: 10.1038/npp.2015.373.Peer-Reviewed Original ResearchConceptsBlood pressureHeart rateFemale smokersRandomized double-blind crossover designDouble-blind crossover designSubjective effectsTobacco-dependent subjectsSex differencesDiastolic blood pressureIntravenous Nicotine Self-AdministrationSelf-administration ratesNicotine Self-AdministrationDose-response functionNicotine dosesNicotine doseTobacco dependenceIntravenous nicotineCrossover designSelf-AdministrationReinforcement thresholdSmokersInfusionNicotineForced-choice trialsAversive responses
2001
Intravenous cocaine increases plasma epinephrine and norepinephrine in humans
Sofuoglu M, Nelson D, Babb D, Hatsukami D. Intravenous cocaine increases plasma epinephrine and norepinephrine in humans. Pharmacology Biochemistry And Behavior 2001, 68: 455-459. PMID: 11325399, DOI: 10.1016/s0091-3057(01)00482-8.Peer-Reviewed Original ResearchConceptsNorepinephrine concentrationsPlasma epinephrineHeart rate changesBlood pressureCocaine injectionHuman studiesPeak plasma epinephrineSympathoadrenal system activationPlacebo-controlled studyDiastolic blood pressureSystolic blood pressureDose of cocaineMale cocaine usersPlasma norepinephrineEpinephrine levelsSympathoadrenal systemCocaine administrationIntravenous injectionSystem activationIntravenous cocaineEpinephrineConsecutive daysNorepinephrineCocaineCocaine users
2000
Carvedilol affects the physiological and behavioral response to smoked cocaine in humans
Sofuoglu M, Brown S, Babb D, Pentel P, Hatsukami D. Carvedilol affects the physiological and behavioral response to smoked cocaine in humans. Drug And Alcohol Dependence 2000, 60: 69-76. PMID: 10821991, DOI: 10.1016/s0376-8716(00)80009-5.Peer-Reviewed Original ResearchConceptsAcute treatmentPlacebo-controlled outpatient studyPhysiological effectsEffects of carvedilolDiastolic blood pressureCocaine-induced increasesNumber of cocaineCarvedilol treatmentBlood pressureOral carvedilolOutpatient studyNoradrenergic systemAdrenergic blockersCrack cocaine usersHeart rateCarvedilolBehavioral responsesCocaineCocaine usersCocaine deliveryTreatmentSubjective responsesTreatment conditionsResponseHumansIndividual Differences in the Subjective Response to Smoked Cocaine in Humans
Sofuoglu M, Brown S, Dudish-Poulsen S, Hatsukami D. Individual Differences in the Subjective Response to Smoked Cocaine in Humans. The American Journal Of Drug And Alcohol Abuse 2000, 26: 591-602. PMID: 11097194, DOI: 10.1081/ada-100101897.Peer-Reviewed Original ResearchConceptsHeart rateBaseline Beck Depression Inventory scoresSubjective responsesBeck Depression Inventory scoresDiastolic blood pressureCocaine deliveryEffects of cocaineDepression Inventory scoresCocaine-dependent participantsBlood pressureMale sexCocaine use behaviorBody weightCocaine useSmoked CocaineAlcohol useInventory scoresCocaineCocaine users