2022
Cocaine Use Disorder (CUD): Current Clinical Perspectives
Schwartz EKC, Wolkowicz NR, De Aquino JP, MacLean RR, Sofuoglu M. Cocaine Use Disorder (CUD): Current Clinical Perspectives. Substance Abuse And Rehabilitation 2022, 13: 25-46. PMID: 36093428, PMCID: PMC9451050, DOI: 10.2147/sar.s337338.Peer-Reviewed Original ResearchCocaine use disorderCo-occurring disordersUse disordersCommon co-occurring disordersCurrent clinical perspectivesSubstance use disordersCognitive behavioral therapyMedication treatmentPharmacological treatmentRisk factorsCurrent treatmentDevastating disorderLarger sample sizeTreatment planChronic effectsCocaine useBehavioral treatmentClinical perspectiveBehavioral interventionsDisordersTreatmentFuture studiesMost individualsIndividualsSample sizeModafinil does not reduce cocaine use in methadone-maintained individuals
DeVito EE, Poling J, Babuscio T, Nich C, Carroll KM, Sofuoglu M. Modafinil does not reduce cocaine use in methadone-maintained individuals. Drug And Alcohol Dependence Reports 2022, 2: 100032. PMID: 36310662, PMCID: PMC9615926, DOI: 10.1016/j.dadr.2022.100032.Peer-Reviewed Original ResearchCocaine use disorderCocaine use outcomesOpioid useCognitive behavioral therapyContingency managementCocaine dependenceCognitive functionMethadone-maintained individualsUse outcomesEfficacy of modafinilSelf-reported abstinenceTreatment of CUDStimulant-like effectsPlatform treatmentPercentage of urinesPercent of daysDual opioidModafinil treatmentUse disordersPotential efficacyCocaine useModafinilPlaceboMinimal reportsBehavioral therapy
2019
Randomized placebo-controlled trial of galantamine in individuals with cocaine use disorder
DeVito EE, Carroll KM, Babuscio T, Nich C, Sofuoglu M. Randomized placebo-controlled trial of galantamine in individuals with cocaine use disorder. Journal Of Substance Use And Addiction Treatment 2019, 107: 29-37. PMID: 31757262, PMCID: PMC6918721, DOI: 10.1016/j.jsat.2019.08.009.Peer-Reviewed Original ResearchConceptsCocaine use disorderSignificant treatment group differencesUse disordersEfficacy of galantamineTreatment-seeking cocaine usersCurrent cocaine use disordersGroup differencesCocaine use outcomesSample of individualsTreatment group differencesComorbid opioid use disorderMethadone-maintained individualsMemory capacityAbstinent individualsCocaine useCognitive improvementCognitive outcomesCocaine use reductionCognitive functionUse outcomesCocaine usersGalantamine groupIndividualsDisordersInitial promiseDouble‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use
Carroll KM, DeVito EE, Yip SW, Nich C, Sofuoglu M. Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use. American Journal On Addictions 2019, 28: 238-245. PMID: 31165574, PMCID: PMC9078084, DOI: 10.1111/ajad.12904.Peer-Reviewed Original ResearchConceptsMethadone-maintained individualsOpioid useSecondary analysisMultiple drugsConcurrent cocaine dependenceTrial of galantaminePlacebo-controlled trialDouble-blind placeboIllicit opioid useRandomized clinical trialsCocaine use disorderGalantamine's effectFuture trialsClinical trialsUrine specimenUrine specimensUse disordersOpioidsCholinesterase inhibitorsMaintenance settingCocaine useCocaine dependencePlaceboConcurrent useGalantamine
2014
Progesterone for the reduction of cocaine use in post-partum women with a cocaine use disorder: a randomised, double-blind, placebo-controlled, pilot study
Yonkers KA, Forray A, Nich C, Carroll KM, Hine C, Merry BC, Shaw H, Shaw J, Sofuoglu M. Progesterone for the reduction of cocaine use in post-partum women with a cocaine use disorder: a randomised, double-blind, placebo-controlled, pilot study. The Lancet Psychiatry 2014, 1: 360-367. PMID: 25328863, PMCID: PMC4199242, DOI: 10.1016/s2215-0366(14)70333-5.Peer-Reviewed Original ResearchCocaine use disorderCocaine usePostpartum womenPost trialUse disordersPlacebo-controlled pilot trialOral micronized progesteronePositive urine testPost-partum womenGroup differencesSelf-reported daysMultiple brain functionsUse of cocaineMicronized progesteroneObstetrical clinicTherapeutic breakProgesterone replacementAdverse eventsUS National InstitutesProgesterone treatmentUrine testsPilot trialRate of submissionStudy biostatisticianProgesterone
2000
Characteristics of research volunteers for inpatient cocaine studies Focus on selection bias
Sofuoglu M, Dudish-Poulsen S, Nicodemus K, Babb D, Hatsukami D. Characteristics of research volunteers for inpatient cocaine studies Focus on selection bias. Addictive Behaviors 2000, 25: 785-790. PMID: 11023020, DOI: 10.1016/s0306-4603(00)00064-2.Peer-Reviewed Original ResearchIndividual Differences in the Subjective Response to Smoked Cocaine in Humans
Sofuoglu M, Brown S, Dudish-Poulsen S, Hatsukami D. Individual Differences in the Subjective Response to Smoked Cocaine in Humans. The American Journal Of Drug And Alcohol Abuse 2000, 26: 591-602. PMID: 11097194, DOI: 10.1081/ada-100101897.Peer-Reviewed Original ResearchConceptsHeart rateBaseline Beck Depression Inventory scoresSubjective responsesBeck Depression Inventory scoresDiastolic blood pressureCocaine deliveryEffects of cocaineDepression Inventory scoresCocaine-dependent participantsBlood pressureMale sexCocaine use behaviorBody weightCocaine useSmoked CocaineAlcohol useInventory scoresCocaineCocaine usersPredictors of cardiovascular response to smoked cocaine in humans
Sofuoglu M, Nelson D, Dudish-Poulsen S, Lexau B, Pentel P, Hatsukami D. Predictors of cardiovascular response to smoked cocaine in humans. Drug And Alcohol Dependence 2000, 57: 239-245. PMID: 10661674, DOI: 10.1016/s0376-8716(99)00055-1.Peer-Reviewed Original ResearchConceptsCardiovascular responsesHeart rateHigher baseline blood pressureLong-term cocaine useCocaine useDiminished cardiovascular responseBaseline blood pressureBlood pressure changesAfrican American raceGreater cardiovascular responseCurrent cocaine useHigher body weightCardiovascular complicationsCurrent marijuana useBlood pressureMale sexCocaine administrationCurrent cocaineAmerican raceBody weightCocaineCocaine usersMarijuana usePredictorsPressure changes