2023
Delta‐9‐tetrahydrocannabinol modulates pain sensitivity among persons receiving opioid agonist therapy for opioid use disorder: A within‐subject, randomized, placebo‐controlled laboratory study
De Aquino J, Meyerovich J, Xie C, Ranganathan M, Compton P, Pittman B, Rogan M, Sofuoglu M. Delta‐9‐tetrahydrocannabinol modulates pain sensitivity among persons receiving opioid agonist therapy for opioid use disorder: A within‐subject, randomized, placebo‐controlled laboratory study. Addiction Biology 2023, 28: e13317. PMID: 37644897, PMCID: PMC10468603, DOI: 10.1111/adb.13317.Peer-Reviewed Original ResearchConceptsOpioid use disorderOpioid agonist therapyAgonist therapyMethadone dosesMethadone therapyPain sensitivityUse disordersPlacebo-controlled laboratory studySynergistic antinociceptive effectCognitive adverse effectsSingle oral dosesRisk-benefit profilePain sensitivity measuresCannabinoid receptor systemAntinociceptive effectTHC doseOral dosesOpioid agonistsAcute effectsCannabinoid agonistsPreclinical studiesAbuse potentialOpioid crisisTherapyReceptor system
1991
Cross-tolerance studies in the spinal cord of β-FNA-treated mice provides further evidence for delta opioid receptor subtypes
Sofuoglu M, Portoghese P, Takemori A. Cross-tolerance studies in the spinal cord of β-FNA-treated mice provides further evidence for delta opioid receptor subtypes. Life Sciences 1991, 49: pl153-pl156. PMID: 1658509, DOI: 10.1016/0024-3205(91)90397-t.Peer-Reviewed Original ResearchConceptsDelta opioid receptor subtypesOpioid receptor subtypesAntinociceptive effectReceptor subtypesAntinociceptive ED50 valueDelta-opioid receptor-selective peptideCross-tolerance studiesReceptor-selective peptideSpinal cordTolerance developmentFurther evidenceDPDPEED50 valuesMiceDADLEDAMGOSignificant increaseDSLETSame pretreatmentSubtypesAdministrationSelective peptidesCordFNA
1990
Naloxone produces protracted tolerance in mice treated with a single dose of morphine.
Sofuoglu M, Takemori A. Naloxone produces protracted tolerance in mice treated with a single dose of morphine. Journal Of Pharmacology And Experimental Therapeutics 1990, 254: 836-40. PMID: 2395115.Peer-Reviewed Original Research