2014
FKBP5 variation is associated with the acute and chronic effects of nicotine
Jensen KP, Herman AI, Morean ME, Kranzler HR, Gelernter J, Sofuoglu M. FKBP5 variation is associated with the acute and chronic effects of nicotine. The Pharmacogenomics Journal 2014, 15: 340-346. PMID: 25532758, PMCID: PMC4599366, DOI: 10.1038/tpj.2014.76.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBlack or African AmericanBlood PressureDiagnostic and Statistical Manual of Mental DisordersGene FrequencyGenotypeHeart RateHumansHydrocortisoneInjections, IntravenousNicotineNicotinic AgonistsRNARNA, MessengerSmokingSubstance Withdrawal SyndromeTacrolimus Binding ProteinsWhite PeopleConceptsNicotine withdrawalFKBP5 mRNA expressionNegative drug effectsHeart rateIndependent cohortDrug effectsMRNA expressionMinor alleleChronic behavioral effectsEffects of nicotineStress hormone regulationLower cortisol levelsWarrants further investigationSevere nicotine withdrawalCurrent smokersBlood pressureHeavy smokersQuit attemptsHR responseSmoking behaviorCortisol responseCortisol levelsLower subjective ratingsSmokersChronic effects
2012
Human Laboratory Paradigms in Alcohol Research
Plebani J, Ray L, Morean M, Corbin W, MacKillop J, Amlung M, King A. Human Laboratory Paradigms in Alcohol Research. Alcohol Clinical And Experimental Research 2012, 36: 972-983. PMID: 22309888, PMCID: PMC4167612, DOI: 10.1111/j.1530-0277.2011.01704.x.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholic IntoxicationAlcoholismBehavior, AddictiveCentral Nervous System DepressantsEthanolGenetics, BehavioralHumansPharmacogeneticsResearch DesignSubstance Withdrawal SyndromeConceptsHuman laboratory studiesAlcohol cravingAlcohol researchHuman laboratory paradigmsMechanisms of riskField of alcoholAlcohol phenotypesNeurobehavioral mechanismsAlcohol pharmacotherapyLaboratory paradigmAlcohol effectsExperimental laboratory approachAlcohol riskNeuropharmacological effectsMedication developmentPhenotype refinementTranslational phenotypesAlcohol usersCravingTreatment responsePhenotypically distinct subtypesFindings to studiesAlcoholAlcoholic etiologyBehavioral economics