Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder
Yadav S, Bhat A, Hashem S, Nisar S, Kamal M, Syed N, Temanni M, Gupta R, Kamran S, Azeem M, Srivastava A, Bagga P, Chawla S, Reddy R, Frenneaux M, Fakhro K, Haris M. Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder. Translational Psychiatry 2021, 11: 349. PMID: 34091591, PMCID: PMC8179928, DOI: 10.1038/s41398-021-01473-w.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderNeurobiology of ADHDHyperactivity disorderSevere brain injuryNew treatment modalitiesDevelopment of ADHDBrain circuit functionNovel clinical biomarkersChildhood-onset disordersStrong genetic associationNeurodevelopmental assessmentPremature birthADHD brainTreatment modalitiesBrain injuryBrain changesPrecise etiologyPsychiatric disordersAnimal modelsADHD patientsTherapeutic interventionsNeural abnormalitiesClinical biomarkersNeurodevelopmental issuesSignificant association