2023
Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors
Puklin L, Harrigan M, Cartmel B, Sanft T, Gottlieb L, Zhou B, Ferrucci L, Li F, Spiegelman D, Sharifi M, Irwin M. Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors. Cancers 2023, 15: 4719. PMID: 37835412, PMCID: PMC10571774, DOI: 10.3390/cancers15194719.Peer-Reviewed Original ResearchBreast cancer survivorsCancer survivorsLifestyle interventionPhysical activityQuality of lifeBody weightWaitlist groupDiet qualitySelf-reported body weightWeight lossFavorable weight changeHealthy weight lossBody mass indexHealthy body weightGreater weight lossEvidence-based materialsDiverse healthcare settingsIntervention armMass indexClinical practicePositive behavior changeHealthcare settingsSurvivorsWeight changeInterventionDiet and physical activity interventions in Black and Latina women with breast cancer: A scoping review
Pichardo M, Sanft T, Ferrucci L, Romero-Ramos Y, Cartmel B, Harrigan M, Velazquez A, Fayanju O, Winer E, Irwin M. Diet and physical activity interventions in Black and Latina women with breast cancer: A scoping review. Frontiers In Oncology 2023, 13: 1079293. PMID: 36994212, PMCID: PMC10040823, DOI: 10.3389/fonc.2023.1079293.Peer-Reviewed Original ResearchBreast cancer survivorsPhysical activity interventionsLifestyle interventionCancer survivorsActivity interventionsLatina womenEfficacy trialsBreast cancerLatina breast cancer survivorsTrial of dietOne-year followFavorable behavioral changesBreast cancer diagnosisPrimary outcomeAvailable peer-reviewed literatureFuture trialsInformal care giversPilot trialSustained behavior changeEfficacy studiesHealthful lifestyleCare giversTrialsWeight lossCancer diagnosis
2022
Impact of a randomized weight loss trial on breast tissue markers in breast cancer survivors
Dieli-Conwright CM, Harrigan M, Cartmel B, Chagpar A, Bai Y, Li FY, Rimm DL, Pusztai L, Lu L, Sanft T, Irwin ML. Impact of a randomized weight loss trial on breast tissue markers in breast cancer survivors. Npj Breast Cancer 2022, 8: 29. PMID: 35256599, PMCID: PMC8901848, DOI: 10.1038/s41523-022-00396-z.Peer-Reviewed Original ResearchBreast cancer survivorsWeight loss interventionBreast tissue biopsiesUsual careLoss interventionCancer survivorsWeight lossBreast cancerTissue markersTissue biopsiesLifestyle behavioural interventionUsual care groupSerum insulin levelsWeight loss trialWeight loss groupBreast cancer treatmentBreast tissue markersInsulin receptor levelsInflammatory markersAdiponectin levelsSerum leptinCare groupInsulin levelsSerum biomarkersBlood draw
2021
Effect of the Lifestyle, Exercise, and Nutrition (LEAN) Study on Long-Term Weight Loss Maintenance in Women with Breast Cancer
Lisevick A, Cartmel B, Harrigan M, Li F, Sanft T, Fogarasi M, Irwin ML, Ferrucci LM. Effect of the Lifestyle, Exercise, and Nutrition (LEAN) Study on Long-Term Weight Loss Maintenance in Women with Breast Cancer. Nutrients 2021, 13: 3265. PMID: 34579142, PMCID: PMC8469752, DOI: 10.3390/nu13093265.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsLong-term weight loss maintenanceUsual care groupWeight loss maintenanceCancer survivorsStudy completionCare groupLoss maintenanceWeight lossBody weightLong-term weight maintenanceShort-term weight lossLong-term weight gainModest weight lossOverweight/obesityElectronic health recordsLifestyle interventionWeight maintenanceBreast cancerWeight trajectoriesWeight gainCurve analysisNutrition studiesWeight changeHealth recordsRandomized trial of weight loss on circulating ghrelin levels among breast cancer survivors
Puklin L, Cartmel B, Harrigan M, Lu L, Li FY, Sanft T, Irwin ML. Randomized trial of weight loss on circulating ghrelin levels among breast cancer survivors. Npj Breast Cancer 2021, 7: 49. PMID: 33976224, PMCID: PMC8113314, DOI: 10.1038/s41523-021-00260-6.Peer-Reviewed Original ResearchBreast cancer survivorsBody mass indexCancer survivorsGhrelin levelsLifestyle interventionUsual careWeight lossPg/Higher ghrelin levelsWeight loss interventionLean body massSix-month changesGreater weight lossWeight regainLoss interventionStudy armsMass indexWeight maintenanceBlood biomarkersHormone ghrelinBlood samplesGhrelinBody compositionBody weightBaseline associationsExamining the effect of obesity-associated gene variants on breast cancer survivors in a randomized weight loss intervention
Nguyen T, Irwin ML, Dewan AT, Cartmel B, Harrigan M, Ferrucci LM, Sanft T, Li F, Lu L, Salinas YD. Examining the effect of obesity-associated gene variants on breast cancer survivors in a randomized weight loss intervention. Breast Cancer Research And Treatment 2021, 187: 487-497. PMID: 33677781, DOI: 10.1007/s10549-021-06151-5.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsUsual care groupWeight loss interventionCancer survivorsLoss interventionCare groupFTO rs9939609Percent body fat changesWeight lossMeaningful weight lossBody fat changesBody mass indexObesity-associated gene FTOObesity-associated gene variantsPercent body fatGreater weight lossLifestyle interventionMass indexTreatment armsIntervention groupBreast cancerBody fatFat changesPurposeOur studyHealthy eating
2018
Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: the lifestyle, exercise, and nutrition (LEAN) study
Sanft T, Usiskin I, Harrigan M, Cartmel B, Lu L, Li FY, Zhou Y, Chagpar A, Ferrucci LM, Pusztai L, Irwin ML. Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: the lifestyle, exercise, and nutrition (LEAN) study. Breast Cancer Research And Treatment 2018, 172: 105-112. PMID: 30062572, DOI: 10.1007/s10549-018-4895-7.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsWeight loss interventionUsual care groupBody mass indexBreast cancer riskCancer survivorsUsual careLoss interventionBreast cancerStage 0Quantitative polymerase chain reactionCare groupTelomere lengthCancer riskStage II/III breast cancerObese breast cancer survivorsWeight lossI breast cancerNon-Hispanic whitesPurposeSome studiesMass indexIntervention groupPhysical activityBlood samplesConclusionOur findingsExercise and weight loss interventions and miRNA expression in women with breast cancer
Adams BD, Arem H, Hubal MJ, Cartmel B, Li F, Harrigan M, Sanft T, Cheng CJ, Pusztai L, Irwin ML. Exercise and weight loss interventions and miRNA expression in women with breast cancer. Breast Cancer Research And Treatment 2018, 170: 55-67. PMID: 29511965, PMCID: PMC6444907, DOI: 10.1007/s10549-018-4738-6.Peer-Reviewed Original ResearchConceptsBaseline body mass indexBC survivorsTumor recurrenceWeight gainWeight lossBreast cancer survivorsSerum miRNA expressionWeight loss interventionBody mass indexWeight loss trialCancer-related deathIndependent clinical trialsMiRNA expressionSix-month interventionCanonical pathwaysTop canonical pathwaysPhysical exercise trialsIngenuity Pathway AnalysisIngenuity Pathway Analysis softwareSporadic BCDevelopment of cancerLoss interventionMass indexCancer survivorsExercise trials
2015
Randomized Trial Comparing Telephone Versus In-Person Weight Loss Counseling on Body Composition and Circulating Biomarkers in Women Treated for Breast Cancer: The Lifestyle, Exercise, and Nutrition (LEAN) Study
Harrigan M, Cartmel B, Loftfield E, Sanft T, Chagpar AB, Zhou Y, Playdon M, Li F, Irwin ML. Randomized Trial Comparing Telephone Versus In-Person Weight Loss Counseling on Body Composition and Circulating Biomarkers in Women Treated for Breast Cancer: The Lifestyle, Exercise, and Nutrition (LEAN) Study. Journal Of Clinical Oncology 2015, 34: 669-676. PMID: 26598750, PMCID: PMC4872022, DOI: 10.1200/jco.2015.61.6375.Peer-Reviewed Original ResearchConceptsWeight loss counselingC-reactive protein levelsUsual careTelephone counselingPhysical activityBody compositionSerum biomarkersBreast cancerPerson counselingWeight loss intervention groupStage I breast cancerEffective weight loss strategyWeight lossI breast cancerBreast cancer survivorsBody mass indexBreast cancer mortalityWeight loss strategiesProtein levelsBreast cancer treatmentMean BMIUC groupMass indexCancer survivorsCancer mortality
2013
Weight Loss Intervention for Breast Cancer Survivors: A Systematic Review
Playdon M, Thomas G, Sanft T, Harrigan M, Ligibel J, Irwin M. Weight Loss Intervention for Breast Cancer Survivors: A Systematic Review. Current Breast Cancer Reports 2013, 5: 222-246. PMID: 26605003, PMCID: PMC4655116, DOI: 10.1007/s12609-013-0113-0.Peer-Reviewed Original ResearchWeight loss interventionBreast cancer survivorsMeaningful weight lossLoss interventionCancer survivorsWeight lossWeight loss intervention trialLong-term weight maintenanceCardiovascular risk factorsSuccessful weight lossBreast cancer recurrenceSmall study sample sizesBreast cancer prognosisSignificant weight lossBreast cancer diagnosisWeight regainPrimary outcomeWeight maintenanceIntervention trialsInterventional studyRisk factorsCancer recurrenceBreast cancerStudy sample sizePhysical activity